Attenuated neutralization, maintained specificity: humoral response to SARS-CoV-2 booster in kidney allograft recipients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F25%3A00085176" target="_blank" >RIV/00023001:_____/25:00085176 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0732889324003754?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0732889324003754?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.diagmicrobio.2024.116550" target="_blank" >10.1016/j.diagmicrobio.2024.116550</a>
Alternative languages
Result language
angličtina
Original language name
Attenuated neutralization, maintained specificity: humoral response to SARS-CoV-2 booster in kidney allograft recipients
Original language description
Despite the lower virulence of current SARS-CoV-2 variants and high rates of vaccinated and previously infected subjects, COVID-19 remains a persistent threat in kidney transplant recipients (KTRs). This study evaluated the parameters of anti-SARS-CoV-2 antibody production in 120 KTRs. The production of neutralizing antibodies in KTRs, following booster vaccination with the mRNA vaccine BNT162b2, was significantly decreased and their decline was faster than in healthy subjects. Factors predisposing to the downregulation of anti-SARS-CoV-2 neutralizing antibodies included age, lower estimated glomerular filtration rate, and a full dose of mycophenolate mofetil. Neutralizing antibodies correlated with those targeting the SARS-CoV-2 receptor binding domain (RBD), SARS-CoV-2 Spike trimmer, total SARS-CoV-2 S1 protein, as well as with antibodies to the deadly SARSCoV-1 virus. No cross-reactivity was found with antibodies against seasonal coronaviruses. KTRs exhibited lower postvaccination production of neutralizing antibodies against SARS-CoV-2; however, the specificity of their humoral response did not differ compared to healthy subjects.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10606 - Microbiology
Result continuities
Project
<a href="/en/project/NU22-C-126" target="_blank" >NU22-C-126: Aspects of immune response and efficacy of booster dose of SARS-CoV-2 mRNA vaccine in kidney transplant recipients</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Diagnostic microbiology and infectious disease
ISSN
0732-8893
e-ISSN
1879-0070
Volume of the periodical
111
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
"art. no. 116550"
UT code for WoS article
001342332200001
EID of the result in the Scopus database
2-s2.0-85206855890