Determination of biological behavior of solitary fibrous tumors : correlation of expression of Ki-67, TPX2 and TERT mRNA subunit level and NAB2-STAT6 fusion compared to morphological aspects of SFTs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00083420" target="_blank" >RIV/00023001:_____/22:00083420 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/22:10434433 RIV/00216208:11120/22:43922655 RIV/00216208:11130/22:10434433 RIV/00064190:_____/22:N0000051
Result on the web
<a href="http://www.elis.sk/download_file.php?product_id=7447&session_id=3mmgur8m98gn2ehj1q015na1s7" target="_blank" >http://www.elis.sk/download_file.php?product_id=7447&session_id=3mmgur8m98gn2ehj1q015na1s7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/neo_2021_210511N642" target="_blank" >10.4149/neo_2021_210511N642</a>
Alternative languages
Result language
angličtina
Original language name
Determination of biological behavior of solitary fibrous tumors : correlation of expression of Ki-67, TPX2 and TERT mRNA subunit level and NAB2-STAT6 fusion compared to morphological aspects of SFTs
Original language description
We present a retrospective study of 65 cases of solitary fibrous tumors (SFTs) of several localizations including the most common site of origin in the pleura and lungs. SFTs are mesenchymal fibroblastic tumors with an unpredictable biological potential ranging from benign to malignant. We investigated morphologic characteristics, proliferation activity evaluated by immunohistochemical expression of Ki-67 antigen, and the existence of NAB2-STAT6 fusion gene together with Ki-67, TPX2, and TERT mRNA expression levels. The aim was to define relationships between proliferation activity and biological potential and progression of the disease. We measured Ki-67, TPX2, and TERT mRNA levels using quantitative real-time reverse transcription PCR (RQ-RT-PCR). We observed a significant association between increased Ki-67 and TERT mRNA levels and the SFTs with malignant potential. Also, we investigated the effect of TERT promoter mutation on telomerase activation and patient outcome in our SFT cohort. We verified that TERT promoter mutation was frequent (36.6%) and present in a majority of malignant SFTs and SFTs with uncertain biological behavior. TERT promoter mutation alone predicted the disease recurrence.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
—
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neoplasma
ISSN
0028-2685
e-ISSN
1338-4317
Volume of the periodical
69
Issue of the periodical within the volume
1
Country of publishing house
SK - SLOVAKIA
Number of pages
8
Pages from-to
28-35
UT code for WoS article
000818525600003
EID of the result in the Scopus database
2-s2.0-85124497624