Bioprosthetic total artificial heart implantation does not Induce chronic inflammation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00083437" target="_blank" >RIV/00023001:_____/22:00083437 - isvavai.cz</a>
Result on the web
<a href="https://journals.lww.com/asaiojournal/Abstract/2022/11000/Bioprosthetic_Total_Artificial_Heart_Implantation.6.aspx" target="_blank" >https://journals.lww.com/asaiojournal/Abstract/2022/11000/Bioprosthetic_Total_Artificial_Heart_Implantation.6.aspx</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/MAT.0000000000001820" target="_blank" >10.1097/MAT.0000000000001820</a>

Result language
angličtina
Original language name
Bioprosthetic total artificial heart implantation does not Induce chronic inflammation
Original language description
The Aeson total artificial heart (A-TAH) has been developed for patients at risk of death from biventricular failure. We aimed to assess the inflammatory status in nine subjects implanted with the A-TAH in kinetics over one year. Laboratory assessment of leukocyte counts, inflammatory cytokines assay, and peripheral blood mononuclear cell collection before and after A-TAH implantation. Leukocyte counts were not significantly modulated according to time after A-TAH implantation (coefficient of the linear mixed effect model with 95% CI, -0.05 (-0.71 to -0.61); p = 0.44). We explored inflammatory cytokine after A-TAH and did not observe, at any time, a modified profile compared to pre-implantation values (all p-values > 0.05). Finally, we compared the distribution of circulating immune cell subpopulations identified based on sequential expression patterns for multiple clusters of differentiation. None of the population explored had significant modulation during the 12-month follow-up (all p-values > 0.05). In conclusion, using a cytokine multiplex assay combined with a flow cytometry approach, we demonstrated the absence of inflammatory signals in peripheral blood over a period of 12 months following A-TAH implantation.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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