Association between gestational diabetes mellitus and bioavailability of insulin-like growth factors and role of their binding proteins

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00083557" target="_blank" >RIV/00023001:_____/22:00083557 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/22:10453005 RIV/00064165:_____/22:10453005

Result on the web

<a href="https://reader.elsevier.com/reader/sd/pii/S1096637422000685?token=4301BF2AA3471A342851273D5E9AEBA989791A462E1DE190A29B59DB2A67D493B3EBAFE4D7A003682E9B28A9FAAC5E1E&originRegion=eu-west-1&originCreation=20230206123107" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S1096637422000685?token=4301BF2AA3471A342851273D5E9AEBA989791A462E1DE190A29B59DB2A67D493B3EBAFE4D7A003682E9B28A9FAAC5E1E&originRegion=eu-west-1&originCreation=20230206123107</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ghir.2022.101511" target="_blank" >10.1016/j.ghir.2022.101511</a>

Result language

angličtina

Original language name

Association between gestational diabetes mellitus and bioavailability of insulin-like growth factors and role of their binding proteins

Original language description

Objective: Insulin-like growth factors (IGFs) are involved in regulating growth and metabolism and increase in-sulin sensitivity, improve glucose metabolism, and are potentially related to gestational diabetes mellitus (GDM) and its complications for mothers and fetuses.Design: This study aimed to assess serum levels and cord blood levels of IGF system components in pregnant women with (39 participants) and without GDM (22 participants). Blood samples were obtained at 28-32 and 36-38 weeks of gestation and 6-12 months after delivery. Cord blood samples were obtained during delivery. Results between both groups as well as between single visits were statistically compared.Results: Both IGF1 and IGF2 maternal serum levels did not differ between the GDM and non-GDM groups. However, levels of IGF-binding proteins (IGFBPs) were different. IGFBP4 levels were decreased during pregnancy and after delivery in women with GDM, while IGFBP7 levels were increased during pregnancy in women with GDM. Cord blood IGFBP3 and IGFBP7 levels were increased (p &lt; 0.001 for IGFBP3, p = 0.003 for IGFBP7), while IGFBP4 levels were decreased (p &lt; 0.001) in the GDM group compared with the non-GDM group. Conclusions: Although IGF levels did not differ, changes in their function level could still persist possibly because of the effects of the binding proteins, especially their promoting or inhibitory effects on IGFs. These results should be considered in interpretation of IGF levels.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/NU20-01-00067" target="_blank" >NU20-01-00067: The effect of diabetes compensation on placental function and fetal circulation in pregnant women with type 1 diabetes mellitus.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Growth hormone &amp; IGF research

ISSN

1096-6374

e-ISSN

1532-2238

Volume of the periodical

67

Issue of the periodical within the volume

December

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

"art. no. 101511"

UT code for WoS article

000904437500002

EID of the result in the Scopus database

2-s2.0-85140918913