Insulin-like growth factor axis in pregnancy and gestational diabetes mellitus

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078600" target="_blank" >RIV/00023001:_____/19:00078600 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10400363 RIV/00216208:11120/19:43918610 RIV/00023761:_____/19:N0000025 RIV/00064173:_____/19:N0000105 RIV/00064165:_____/19:10400363
Result on the web
<a href="http://www.biomed.cas.cz/physiolres/pdf/2019/68_807.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/2019/68_807.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.934093" target="_blank" >10.33549/physiolres.934093</a>

Result language
angličtina
Original language name
Insulin-like growth factor axis in pregnancy and gestational diabetes mellitus
Original language description
The insulin-like growth factor (IGF) is involved in the regulation of growth and metabolism. The aim of this study was to determine selected parameters of IGF system at systemic and local levels [subcutaneous (SAT) and visceral adipose tissue (VAT)] to assess its possible role in gestational diabetes mellitus (GDM). 37 pregnant women (21 with GDM and 16 without GDM) and 15 age-matched non-pregnant females were included in the study. Blood samples were taken in 28-32 and 36-38 weeks of gestation and 6-12 months after delivery. SAT and VAT samples were obtained during delivery or surgery. Compared with nonpregnant women, serum IGF-1 and IGFBP-3 were increased in both groups of pregnant women. IGF-2 was elevated only in GDM women from 36 weeks of gestation culminating 6 months after delivery (p=0.003). Serum IGFBP-3 was increased and IGFBP-4 decreased in GDM women vs. pregnant women without GDM during the whole study (IGFBP-3: p<0.001 for GDM vs. non-GDM; IGFBP-4: p=0.004 for GDM vs. non-GDM). Pregnant women with GDM had decreased mRNA expression of IGF-1, IGF-1R and IGF-2R and IGFBP-4 in VAT and IGF-1R in SAT compared to pregnant women without GDM. Changes in local activity of IGF are associated with the development of GDM.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)

Project
<a href="/en/project/NV15-27630A" target="_blank" >NV15-27630A: Endocrine function of adipose tissue in the etiopathogenesis of the gestational diabetes.</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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