Non-altered incretin secretion in women with impaired fasting plasma glucose in the early stage of pregnancy: a case control study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00083624" target="_blank" >RIV/00023001:_____/23:00083624 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/23:73621585 RIV/00098892:_____/23:10157914
Result on the web
<a href="https://dmsjournal.biomedcentral.com/articles/10.1186/s13098-023-00981-7#Fun" target="_blank" >https://dmsjournal.biomedcentral.com/articles/10.1186/s13098-023-00981-7#Fun</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s13098-023-00981-7" target="_blank" >10.1186/s13098-023-00981-7</a>
Alternative languages
Result language
angličtina
Original language name
Non-altered incretin secretion in women with impaired fasting plasma glucose in the early stage of pregnancy: a case control study
Original language description
BackgroundsGlucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) may be involved in pathogenesis of gestational diabetes mellitus (GDM). The aim was to compare GLP-1 and GIP production in fasting state and during 3 h mixed meal tolerance test (MMTT) measured by mean area under the curve (AUC) between pregnant women with normal and impaired fasting glucose in an early phase of pregnancy, and healthy non-pregnant controls.MethodsThis study was undertaken as a case-control study. Repeated measurement of fasting plasma glucose >= 5.1 mmol/L and < 7.0 mmol/L during the first trimester of pregnancy and exclusion of overt diabetes according to IADSPG criteria was used to find women with impaired fasting glucose (n = 22). Age-matched controls consisted of healthy pregnant (n = 25) and non-pregnant (n = 24) women. In addition to incretins, anthropometric parameters and markers of insulin resistance and beta-cell function were assessed. Variables were summarized as median (interquartile range).ResultsFasting GLP-1 and GIP concentration or their AUC during MMTT did not significantly differ between pregnant women with impaired fasting plasma glucose [GLP-1(AUC) 19.0 (53.1) and GIP(AUC) 302 (100) pg/mL/min] and healthy pregnant women [GLP-1(AUC) 16.7 (22.3) and GIP(AUC) 297 (142) pg/mL/min] or non-pregnant controls [GLP-1(AUC) 16.8 (9.8) and for GIP(AUC) 313 (98) pg/mL/min]. Although women with impaired fasting glucose were more obese and showed decreased beta-cell function, there were not significant correlations between incretin production and parameters of insulin secretion, insulin resistance, or obesity.ConclusionsWomen with impaired fasting plasma glucose did not show altered incretin production in the first trimester of pregnancy. In contrast to type 2 diabetes, impaired incretin secretion does not seem to play a major role in the early development of GDM.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Diabetology & metabolic syndrome
ISSN
1758-5996
e-ISSN
1758-5996
Volume of the periodical
15
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
"art. no. 12"
UT code for WoS article
000919623700001
EID of the result in the Scopus database
2-s2.0-85146959440