BMI-associated anti-apolipoprotein A-1 positivity in healthy adults after mRNA-vaccination against COVID-19

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00083821" target="_blank" >RIV/00023001:_____/23:00083821 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/23:10458567 RIV/00216208:11120/23:43925317 RIV/00064173:_____/23:43925317

Result on the web

<a href="https://www.mdpi.com/2076-393X/11/3/670" target="_blank" >https://www.mdpi.com/2076-393X/11/3/670</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/vaccines11030670" target="_blank" >10.3390/vaccines11030670</a>

Result language

angličtina

Original language name

BMI-associated anti-apolipoprotein A-1 positivity in healthy adults after mRNA-vaccination against COVID-19

Original language description

Elevated anti-apolipoprotein A-1 (AAA1) antibody levels associated with cardiovascular risk have been observed in previously SARS-CoV-2-infected or COVID-19-vaccinated individuals. Since patient safety is generally a priority in vaccination, we sought to investigate AAA1 antibody levels in healthy adults after mRNA vaccination. We conducted a prospective cohort study in healthy adult volunteers recruited from military workers of the Transport Air Base in Prague who had received two doses of mRNA vaccines. Anti-apolipoprotein A-1 antibody levels were determined using ELISA from serum samples obtained at three and four time points after the first and second vaccine doses, respectively, within almost 17 weeks of follow-up. The transient AAA1 positivity rate achieved 24.1% (95% confidence interval CI: 15.4-34.7%), i.e., 20 out of 83 participants had at least one positive post-vaccination sample, with a repeat positivity confirmed in only 5 of them. This rate was associated with a BMI &gt; 26 kg/m(2), as documented by an adjusted odds ratio of 6.79 (95% CI: 1.53-30.01). In addition, the highest positivity rate of 46.7% (21.3-73.4%) was observed in obese subjects with &gt;30 kg/m(2). Since the incidence rate of AAA1 positivity remained unchanged after the first and second vaccine doses, any relationship between AAA1 positivity and mRNA vaccination was inconclusive. The present study showed a transient AAA1 positivity rate associated with overweight or obesity without a proven association with mRNA vaccination.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30102 - Immunology

Project

<a href="/en/project/NU22-A-125" target="_blank" >NU22-A-125: The impact of SARS-CoV-2 on early manifestation of acute coronary syndrome, its complications and polyvascular disease</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Vaccines (Basel) [online]

ISSN

2076-393X

e-ISSN

2076-393X

Volume of the periodical

11

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

8

Pages from-to

"art. no. 670"

UT code for WoS article

000959161200001

EID of the result in the Scopus database

2-s2.0-85152073316