Factors influencing persistence of diphtheria immunity and immune response to a booster dose in healthy Slovak adults
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078400" target="_blank" >RIV/00023001:_____/19:00078400 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/19:43918896
Result on the web
<a href="https://www.mdpi.com/2076-393X/7/4/139" target="_blank" >https://www.mdpi.com/2076-393X/7/4/139</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/vaccines7040139" target="_blank" >10.3390/vaccines7040139</a>
Alternative languages
Result language
angličtina
Original language name
Factors influencing persistence of diphtheria immunity and immune response to a booster dose in healthy Slovak adults
Original language description
We assessed the long-term persistence of humoral immunity against diphtheria in adults with childhood vaccination and the immunogenicity of a booster dose considering demographic, behavioural and vaccinating factors. We conducted a trial in 200 healthy Slovak adults aged 24-65 years, immunised against diphtheria in childhood and against tetanus at regular 10-15 year intervals, and receiving a dose of a tetanus-diphtheria toxoid vaccine. The response was determined by ELISA antibody concentrations of paired sera before and at 4 weeks post-vaccination. A seroprotection rate of 21% (95% confidence interval, CI 15.6-27.3%) was found in adults up to 59 years since the last vaccination with seroprotective levels of antibodies against diphtheria ≥0.1 IU/mL and a geometric mean concentration of 0.05 IU/mL. Conversely, seropositive levels ≥0.01 IU/mL were observed in 98% of adults (95% CI 95-99.5%). Booster-induced seroprotection was achieved in 78% of adults (95% CI 71.6-83.5%) clearly depending on pre-booster antibody levels correlating with age and time since the last vaccination. Moreover, only 54.2% of smokers and 53.3% of patients on statins exhibited seroprotection. Booster vaccination against diphtheria was unable to confer seroprotection in all recipients of only childhood vaccination.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Vaccines (Basel) [online]
ISSN
2076-393X
e-ISSN
—
Volume of the periodical
7
Issue of the periodical within the volume
4
Country of publishing house
CH - SWITZERLAND
Number of pages
9
Pages from-to
"E139"
UT code for WoS article
000505709700067
EID of the result in the Scopus database
2-s2.0-85074095322