Predictors of the immune response to booster immunisation against tetanus in Czech healthy adults

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F18%3A43916989" target="_blank" >RIV/00216208:11120/18:43916989 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1017/S095026881800242X" target="_blank" >https://doi.org/10.1017/S095026881800242X</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1017/S095026881800242X" target="_blank" >10.1017/S095026881800242X</a>

Result language

angličtina

Original language name

Predictors of the immune response to booster immunisation against tetanus in Czech healthy adults

Original language description

An evaluation of the relationship between predictors and immune response was conducted using data obtained from a clinical trial in 200 Czech healthy adults aged 24-65 years receiving a booster dose of a monovalent tetanus vaccine in 2017. The response was determined from ELISA antibody concentrations of paired sera obtained before and 4 weeks after the immunisation. While all subjects with initial antibody levels 2.2 IU/ml. The immune response was not affected by sex, age, tetanus vaccine type, concomitant medication, related adverse events or post-vaccination period since there were no significant differences in geometric mean concentrations or seroconversion rates. The seroconversion rate of 56% in smokers was significantly lower than that of 73% achieved in non-smokers. Although the seroconversion rates did not differ between individuals with normal or higher body weight, the adjusted odds ratio (1.3; 95% Cl 1.08-1.60) revealed a positive correlation between seroconversion rate and body mass index (BMI). Although the vaccine-induced response was influenced by pre-vaccination antibody levels, smoking or BMI, the booster immunisation against tetanus produced a sufficient response regardless the predictors.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30304 - Public and environmental health

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Epidemiology &amp; Infection

ISSN

0950-2688

e-ISSN

—

Volume of the periodical

146

Issue of the periodical within the volume

16

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

2079-2085

UT code for WoS article

000449646700010

EID of the result in the Scopus database

2-s2.0-85052951338