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Simultaneous biventricular pressure-volume analysis in rats

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00083991" target="_blank" >RIV/00023001:_____/23:00083991 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11130/23:10465830 RIV/00064203:_____/23:10465830

  • Result on the web

    <a href="http://www.jpp.krakow.pl/journal/archive/04_23/pdf/10.26402/jpp.2023.2.02.pdf" target="_blank" >http://www.jpp.krakow.pl/journal/archive/04_23/pdf/10.26402/jpp.2023.2.02.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.26402/jpp.2023.2.02" target="_blank" >10.26402/jpp.2023.2.02</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Simultaneous biventricular pressure-volume analysis in rats

  • Original language description

    The pressure-volume (PV) analysis is used for an accurate assessment of load-independent cardiac function and is important for the study of cardiovascular diseases and various therapeutic modalities. PV analysis is often performed on one of the ventricles, or on both ventricles but sequentially. Since both ventricles interact with each other and their functions are mutually interdependent, especially in various disease conditions such as pulmonary hypertension or heart failure, it is important to quantify the function of both ventricles at the same time. Therefore, our aim was to describe a standardized protocol for simultaneous right (RV) and left (LV) ventricle of PV analysis, including an especially controllable preload reduction manoeuver. Our second aim was to test whether simultaneous catheterization of both LV and RV is necessary for the determination of biventricular PV relationship compared to sequential measurement of both ventricles separately. In this article, we showed the feasibility and the value of simultaneous biventricular PV analysis in the measurement of contractility parameters (end-systolic pressure-volume relationship (ESPVR), ventricular pressure over time (dP/dt)max, divided by end-diastolic volume (dP/dt max-EDV)) with a comparison to the sequential measurement of the RV and LV ventricles separately. We described in detail the protocol for simultaneous biventricular PV analysis in rats using a pair of conductance-micromanometer catheters with a preload-reducing manoeuver using balloon catheter inflation in the inferior vena cava. We also described technical tips and show examples of PV loop data obtained in normotensive and hypertensive rats, with and without heart failure due to volume overload. This protocol could be useful for scientists studying hemodynamics and cardiac contractility in various models of cardiovascular diseases with a focus on biventricular differences and ventricular interdependence. © 2023, Polish Physiological Society. All rights reserved.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30201 - Cardiac and Cardiovascular systems

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of physiology and pharmacology

  • ISSN

    0867-5910

  • e-ISSN

    1899-1505

  • Volume of the periodical

    74

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    PL - POLAND

  • Number of pages

    17

  • Pages from-to

    131-147

  • UT code for WoS article

    001094910400002

  • EID of the result in the Scopus database

    2-s2.0-85164759696