Simultaneous biventricular pressure-volume analysis in rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00083991" target="_blank" >RIV/00023001:_____/23:00083991 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/23:10465830 RIV/00064203:_____/23:10465830
Result on the web
<a href="http://www.jpp.krakow.pl/journal/archive/04_23/pdf/10.26402/jpp.2023.2.02.pdf" target="_blank" >http://www.jpp.krakow.pl/journal/archive/04_23/pdf/10.26402/jpp.2023.2.02.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.26402/jpp.2023.2.02" target="_blank" >10.26402/jpp.2023.2.02</a>
Alternative languages
Result language
angličtina
Original language name
Simultaneous biventricular pressure-volume analysis in rats
Original language description
The pressure-volume (PV) analysis is used for an accurate assessment of load-independent cardiac function and is important for the study of cardiovascular diseases and various therapeutic modalities. PV analysis is often performed on one of the ventricles, or on both ventricles but sequentially. Since both ventricles interact with each other and their functions are mutually interdependent, especially in various disease conditions such as pulmonary hypertension or heart failure, it is important to quantify the function of both ventricles at the same time. Therefore, our aim was to describe a standardized protocol for simultaneous right (RV) and left (LV) ventricle of PV analysis, including an especially controllable preload reduction manoeuver. Our second aim was to test whether simultaneous catheterization of both LV and RV is necessary for the determination of biventricular PV relationship compared to sequential measurement of both ventricles separately. In this article, we showed the feasibility and the value of simultaneous biventricular PV analysis in the measurement of contractility parameters (end-systolic pressure-volume relationship (ESPVR), ventricular pressure over time (dP/dt)max, divided by end-diastolic volume (dP/dt max-EDV)) with a comparison to the sequential measurement of the RV and LV ventricles separately. We described in detail the protocol for simultaneous biventricular PV analysis in rats using a pair of conductance-micromanometer catheters with a preload-reducing manoeuver using balloon catheter inflation in the inferior vena cava. We also described technical tips and show examples of PV loop data obtained in normotensive and hypertensive rats, with and without heart failure due to volume overload. This protocol could be useful for scientists studying hemodynamics and cardiac contractility in various models of cardiovascular diseases with a focus on biventricular differences and ventricular interdependence. © 2023, Polish Physiological Society. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of physiology and pharmacology
ISSN
0867-5910
e-ISSN
1899-1505
Volume of the periodical
74
Issue of the periodical within the volume
2
Country of publishing house
PL - POLAND
Number of pages
17
Pages from-to
131-147
UT code for WoS article
001094910400002
EID of the result in the Scopus database
2-s2.0-85164759696