Right ventricular global dysfunction score : a new concept of right ventricular function assessment in patients with heart failure with reduced ejection fraction (HFrEF)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00084105" target="_blank" >RIV/00023001:_____/23:00084105 - isvavai.cz</a>

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fcvm.2023.1194174/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fcvm.2023.1194174/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fcvm.2023.1194174" target="_blank" >10.3389/fcvm.2023.1194174</a>

Result language

angličtina

Original language name

Right ventricular global dysfunction score : a new concept of right ventricular function assessment in patients with heart failure with reduced ejection fraction (HFrEF)

Original language description

BackgroundRight ventricular (RV) function is currently being evaluated solely according to the properties of RV myocardium. We have tested a concept that in patients with heart failure with reduced ejection fraction (HFrEF), RV assessment should integrate the information about both RV function as well as size. MethodsA total of 836 stable patients with HFrEF (LVEF 23.6 &amp; PLUSMN; 5.8%, 82.8% males, 68% NYHA III/IV) underwent echocardiographic evaluation and were prospectively followed for a median of 3.07 (IQRs 1.11; 4.89) years for the occurrence of death, urgent heart transplantation or implantation of mechanical circulatory support. ResultsRV size (measured as RV-basal diameter, RVD1) was significantly associated with an adverse outcome independent of RV dysfunction grade (p = 0.0002). The prognostic power of RVD1 was further improved by indexing to body surface area (RVD(1)i, p &lt; 0.05 compared to non-indexed value). A novel parameter named RV global dysfunction score (RVGDs) was calculated as a product of RVD(1)i and the degree of RV dysfunction (1-4 for preserved RV function, mild, moderate and severe dysfunction, respectively). RVGDs showed a superior prognostic role compared to RV dysfunction grade alone (&amp; UDelta;AUC &gt;0.03, p &lt; 0.0001). In every subgroup of RVGDs (&lt;20, 20-40, 40-60, &gt;60), patients with milder degree of RV dysfunction but more dilated RV had similar outcome as those with more severe degree of RV dysfunction but smaller RV size (all p &gt; 0.50), independent of tricuspid regurgitation severity and degree of pulmonary hypertension. ConclusionRV dilatation is a manifestation of RV dysfunction. The evaluation of RV performance should integrate the information about both RV size and function.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in cardiovascular medicine

ISSN

2297-055X

e-ISSN

2297-055X

Volume of the periodical

10

Issue of the periodical within the volume

August 4

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

"art. no. 1194174"

UT code for WoS article

001050181900001

EID of the result in the Scopus database

2-s2.0-85168357169