A novel prognostic nomogram predicts premature failure of kidney allografts with IgA nephropathy recurrence

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00084318" target="_blank" >RIV/00023001:_____/23:00084318 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/23:10465993

Result on the web

<a href="https://academic.oup.com/ndt/article/38/11/2627/7172144?login=true" target="_blank" >https://academic.oup.com/ndt/article/38/11/2627/7172144?login=true</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ndt/gfad097" target="_blank" >10.1093/ndt/gfad097</a>

Result language

angličtina

Original language name

A novel prognostic nomogram predicts premature failure of kidney allografts with IgA nephropathy recurrence

Original language description

Background Recurrence of immunoglobulin A nephropathy (IgAN) limits graft survival in kidney transplantation. However, predictors of a worse outcome are poorly understood. Methods Among 442 kidney transplant recipients (KTRs) with IgAN, 83 (18.8%) KTRs exhibited biopsy-proven IgAN recurrence between 1994 and 2020 and were enrolled in the derivation cohort. A multivariable Cox model predicting allograft loss based on clinical data at the biopsy and a web-based nomogram were developed. The nomogram was externally validated using an independent cohort (n = 67). Results Patient age &lt;43 years {hazard ratio [HR] 2.20 [95% confidence interval (CI) 1.41-3.43], P &lt; .001}, female gender [HR 1.72 (95% CI 1.07-2.76), P = .026] and retransplantation status [HR 1.98 (95% CI 1.13-3.36), P = .016] were identified as independent risk factors for IgAN recurrence. Patient age &lt;43 years [HR 2.77 (95% CI 1.17-6.56), P = .02], proteinuria &gt;1 g/24 hours [HR 3.12 (95% CI 1.40-6.91), P = .005] and C4d positivity [HR 2.93 (95% CI 1.26-6.83), P = .013] were found to be associated with graft loss in patients with IgAN recurrence. A nomogram predicting graft loss was constructed based on clinical and histological variables, with a C statistic of 0.736 for the derivation cohort and 0.807 for the external validation cohort. Conclusions The established nomogram identified patients with recurrent IgAN at risk for premature graft loss with good predictive performance.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30217 - Urology and nephrology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nephrology, dialysis, transplantation

ISSN

0931-0509

e-ISSN

1460-2385

Volume of the periodical

38

Issue of the periodical within the volume

11

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

2627-2636

UT code for WoS article

001004085600001

EID of the result in the Scopus database

2-s2.0-85175878393