Cell therapy of severe ischemia in people with diabetic foot ulcers-do we have enough evidence?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00084327" target="_blank" >RIV/00023001:_____/23:00084327 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/23:10469516
Result on the web
<a href="https://link.springer.com/article/10.1007/s40291-023-00667-w" target="_blank" >https://link.springer.com/article/10.1007/s40291-023-00667-w</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s40291-023-00667-w" target="_blank" >10.1007/s40291-023-00667-w</a>
Alternative languages
Result language
angličtina
Original language name
Cell therapy of severe ischemia in people with diabetic foot ulcers-do we have enough evidence?
Original language description
This current opinion article critically evaluates the efficacy of autologous cell therapy (ACT) for chronic limb-threatening ischemia (CLTI), especially in people with diabetes who are not candidates for standard revascularization. This treatment approach has been used in 'no-option' CLTI in the last two decades and more than 1700 patients have received ACT worldwide. Here we analyze the level of published evidence of ACT as well as our experience with this treatment method. Many studies have shown that ACT is safe and an effective method for patients with the most severe lower limb ischemia. However, some trials did not show any benefit of ACT, and there is some heterogeneity in the types of injected cells, route of administration and assessed endpoints. Nevertheless, we believe that ACT plays an important role in a comprehensive treatment of patients with diabetic foot and severe ischemia.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
<a href="/en/project/LX22NPO5104" target="_blank" >LX22NPO5104: National Institute for Research of Metabolic and Cardiovascular Diseases</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular diagnosis and therapy
ISSN
1177-1062
e-ISSN
1179-2000
Volume of the periodical
27
Issue of the periodical within the volume
6
Country of publishing house
NZ - NEW ZEALAND
Number of pages
11
Pages from-to
673-683
UT code for WoS article
001069952500001
EID of the result in the Scopus database
2-s2.0-85171735704