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High RIPK3 expression is associated with a higher risk of early kidney transplant failure

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00084367" target="_blank" >RIV/00023001:_____/23:00084367 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S2589004223019569?pes=vor" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2589004223019569?pes=vor</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.isci.2023.107879" target="_blank" >10.1016/j.isci.2023.107879</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    High RIPK3 expression is associated with a higher risk of early kidney transplant failure

  • Original language description

    Renal ischemia-reperfusion injury (IRI) is associated with reduced allograft survival, and each additional hour of cold ischemia time increases the risk of graft failure and mortality following renal transplantation. Receptor-interacting protein kinase 3 (RIPK3) is a key effector of necroptosis, a regulated form of cell death. Here, we evaluate the first-in-human RIPK3 expression dataset following IRI in kidney transplantation. The primary analysis included 374 baseline biopsy samples obtained from renal allografts 10 minutes after onset of reperfusion. RIPK3 was primarily detected in proximal tubular cells and distal tubular cells, both of which are affected by IRI. Time-to-event analysis revealed that high RIPK3 expression is associated with a significantly higher risk of one-year transplant failure and prognostic for one-year (death-censored) transplant failure independent of donor and recipient associated risk factors in multivariable analyses. The RIPK3 score also correlated with deceased donation, cold ischemia time and the extent of tubular injury. © 2023 The Authors

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30217 - Urology and nephrology

Result continuities

  • Project

  • Continuities

    N - Vyzkumna aktivita podporovana z neverejnych zdroju

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    iScience

  • ISSN

    2589-0042

  • e-ISSN

    2589-0042

  • Volume of the periodical

    26

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    16

  • Pages from-to

    "art. no. 107879"

  • UT code for WoS article

    001110624000001

  • EID of the result in the Scopus database

    2-s2.0-85174810930