All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Impact of circadian rhythm parameters on type 1 diabetes control

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00084391" target="_blank" >RIV/00023001:_____/23:00084391 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Impact of circadian rhythm parameters on type 1 diabetes control

  • Original language description

    Background and aims: Circadian rhythms, which run with a period closeto 24 h, are driven by an internal clock in the brain that responds to thelight/dark changes in our environment. This regulation results in dailyalternating states of alertness and sleepiness. An irregular circadian rhythmwith poor sleep habits has been proven to be a potential risk factor for type2 diabetes mellitus, whereas it is not fully explored how poor sleep hygieneafects type 1 diabetes mellitus (T1DM) control and its complications.Therefore, the aim of our study was to research whether sleep deprivationor misaligned sleep patterns correlate with key T1DM parameters.Materials and methods: A total of 383 patients with T1DM,mean age 46.8 years, mean diabetes duration 25.1 years completed The Munich ChronoType Questionnaire (MCTQ). TheMCTQ provides information on social jetlag - it refers to a discrepancy between sleep time on weekdays and weekends. Weexcluded shift workers or individuals who were travelling duringthe observation period. All patients were prospectively recruitedfrom the diabetes outpatient clinic, and all used effective glucosemonitoring via a subcutaneously implantable sensor device. Themean HbA1c was 53.7 mmol/mol and the mean time in range(TIR) was 69.4%. Data from the MCTQ questionnaire were usedto calculate social jetlag as the difference between the MSF (midsleep phase on free days) and the MSW (mid sleep phase on workdays). MSF on free days were normalized to age- and sex-corrected MSFsasc (“normalized chronotype,” a hypothetical chronotype at age 30). Subjects from the lowest and highest MSFsascdeciles were categorized as “Extremely early” and “Extremelylate” chronotypes (extremes), respectively, and the remainderwere categorized as “Non-extreme” chronotype, which includedslightly early, intermediate, and slightly late chronotypes. Spearman’s nonparametric correlation coefficients were calculated forassessing associations between continuous variables and T-testor ANOVA with Tukey’s post-hoc multiple comparison test forassessing associations between categorical variables and continuous variables.Results: Chronotype and social jetlag did not difer depending ongender. In addition, both chronotype and social jetlag showed no signifcant correlation with HbA1c and TIR (defned as glycaemia 3.9-10mmol/l). Shorter total sleep duration showed a slightly higher incidence of albuminuria (r=-0.19, p=0.019). Extremely early chronotypewas associated with worse mean TIR (compared by ANOVA andTukey test, p=0.029) and worse mean time above glycaemia 13.9mmol/l compared to normal chronotype (p=0.037).Conclusion: Our study showed that the sleep duration was associatedwith both T1DM control and albuminuria. Chronotype or social jetlagdid not signifcantly correlate with the control of T1DM. In the future,we aim to provide insight into further results from larger sample ofsubjects with worse glycaemic control.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

  • OECD FORD branch

    30202 - Endocrinology and metabolism (including diabetes, hormones)

Result continuities

  • Project

    <a href="/en/project/LX22NPO5104" target="_blank" >LX22NPO5104: National Institute for Research of Metabolic and Cardiovascular Diseases</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů