Population-representative study reveals cardiovascular and metabolic disease biomarkers associated with misaligned sleep schedules
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F23%3A00573072" target="_blank" >RIV/67985823:_____/23:00573072 - isvavai.cz</a>
Alternative codes found
RIV/68378025:_____/23:00573072
Result on the web
<a href="https://doi.org/10.1093/sleep/zsad037" target="_blank" >https://doi.org/10.1093/sleep/zsad037</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/sleep/zsad037" target="_blank" >10.1093/sleep/zsad037</a>
Alternative languages
Result language
angličtina
Original language name
Population-representative study reveals cardiovascular and metabolic disease biomarkers associated with misaligned sleep schedules
Original language description
Study ObjectivesSocial jetlag manifests as a difference in sleep timing on workdays and free days. Social jetlag is often associated with shorter, lower-quality sleep, so it is unclear how much the chronic circadian misalignment contributes to observed negative health outcomes. We aimed to (1) investigate associations between social jetlag, chronotype (one of its determinants), and the levels of health markers, (2) describe factors associated with social jetlag, and (3) examine whether working from home can reduce social jetlag.MethodsAdult respondents participated in a nationally representative longitudinal survey of Czech households (individuals in each wave: n(2018/19/20) = 5132/1957/1533), which included Munich ChronoType Questionnaire to evaluate chronotype and social jetlag. A subset provided blood samples (n(2019) = 1957) for detection of nine biomarkers and was surveyed in three successive years (social jetlag calculated for n(2018/19/20) = 3930/1601/1237). Data were analyzed by nonparametric univariate tests and mixed effects multivariate regression with social jetlag, chronotype, sex, age, body-mass index, and reported diseases as predictors and biomarker levels as outcomes.ResultsHigher social jetlag (>= 0.65 h) was significantly associated with increased levels of total cholesterol and low-density lipoprotein cholesterol, particularly in participants older than 50 years (Mann-Whitney, men: p(CHL) = 0.0005, p(LDL) = 0.0009, women: p(CHL) = 0.0079, p(LDL) = 0.0068). Extreme chronotypes were associated with cardiovascular disease risk markers regardless of social jetlag (Kruskal-Wallis, p < 0.0001). Commuting to work and time stress were identified as important contributors to social jetlag. Individual longitudinal data showed that working from home decreased social jetlag and prolonged sleep.ConclusionsWe report significant associations between sleep phase preference, social jetlag, and cardio-metabolic biomarkers.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Sleep
ISSN
0161-8105
e-ISSN
1550-9109
Volume of the periodical
46
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
zsad037
UT code for WoS article
000973377000001
EID of the result in the Scopus database
2-s2.0-85162244955