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Population-representative study reveals cardiovascular and metabolic disease biomarkers associated with misaligned sleep schedules

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F23%3A00573072" target="_blank" >RIV/67985823:_____/23:00573072 - isvavai.cz</a>

  • Alternative codes found

    RIV/68378025:_____/23:00573072

  • Result on the web

    <a href="https://doi.org/10.1093/sleep/zsad037" target="_blank" >https://doi.org/10.1093/sleep/zsad037</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1093/sleep/zsad037" target="_blank" >10.1093/sleep/zsad037</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Population-representative study reveals cardiovascular and metabolic disease biomarkers associated with misaligned sleep schedules

  • Original language description

    Study ObjectivesSocial jetlag manifests as a difference in sleep timing on workdays and free days. Social jetlag is often associated with shorter, lower-quality sleep, so it is unclear how much the chronic circadian misalignment contributes to observed negative health outcomes. We aimed to (1) investigate associations between social jetlag, chronotype (one of its determinants), and the levels of health markers, (2) describe factors associated with social jetlag, and (3) examine whether working from home can reduce social jetlag.MethodsAdult respondents participated in a nationally representative longitudinal survey of Czech households (individuals in each wave: n(2018/19/20) = 5132/1957/1533), which included Munich ChronoType Questionnaire to evaluate chronotype and social jetlag. A subset provided blood samples (n(2019) = 1957) for detection of nine biomarkers and was surveyed in three successive years (social jetlag calculated for n(2018/19/20) = 3930/1601/1237). Data were analyzed by nonparametric univariate tests and mixed effects multivariate regression with social jetlag, chronotype, sex, age, body-mass index, and reported diseases as predictors and biomarker levels as outcomes.ResultsHigher social jetlag (>= 0.65 h) was significantly associated with increased levels of total cholesterol and low-density lipoprotein cholesterol, particularly in participants older than 50 years (Mann-Whitney, men: p(CHL) = 0.0005, p(LDL) = 0.0009, women: p(CHL) = 0.0079, p(LDL) = 0.0068). Extreme chronotypes were associated with cardiovascular disease risk markers regardless of social jetlag (Kruskal-Wallis, p < 0.0001). Commuting to work and time stress were identified as important contributors to social jetlag. Individual longitudinal data showed that working from home decreased social jetlag and prolonged sleep.ConclusionsWe report significant associations between sleep phase preference, social jetlag, and cardio-metabolic biomarkers.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30105 - Physiology (including cytology)

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Sleep

  • ISSN

    0161-8105

  • e-ISSN

    1550-9109

  • Volume of the periodical

    46

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    14

  • Pages from-to

    zsad037

  • UT code for WoS article

    000973377000001

  • EID of the result in the Scopus database

    2-s2.0-85162244955