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Acute hemodynamic effect of a novel dual-vein, multisite biventricular pacing configuration

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00084420" target="_blank" >RIV/00023001:_____/23:00084420 - isvavai.cz</a>

  • Alternative codes found

    RIV/68407700:21460/23:00371273 RIV/00216208:11110/23:10473240

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S2405500X23005200?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2405500X23005200?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.jacep.2023.07.007" target="_blank" >10.1016/j.jacep.2023.07.007</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Acute hemodynamic effect of a novel dual-vein, multisite biventricular pacing configuration

  • Original language description

    Background: Biventricular pacing (BVP) from multiple left ventricular (LV) sites could enhance the efficacy of cardiac resynchronization therapy (CRT) by engaging a greater myocardial mass. Objectives: The goal of this study was to evaluate the acute hemodynamic effect of various multisite pacing (MSP) configurations against conventional BVP. Methods: Twenty patients with nonischemic dilated cardiomyopathy and left bundle branch block (mean age: 59 ± 14 years; LV ejection fraction: 27% ± 6%; native QRS: 171 ± 16 milliseconds) were investigated during a routine CRT implant procedure. In addition to conventional right atrial and right ventricular leads, 2 quadripolar leads were placed in the distant coronary venous branches. LV hemodynamics was evaluated by using a micromanometer-tipped catheter during atrioventricular BVP with 4 LV lead configurations: single-lead conventional BVP; single-lead multipoint pacing; triventricular pacing from distal dipoles of 2 LV leads; and maximum MSP (MSP-Max) from 4 dipoles of 2 LV leads. Results: Compared with right atrial pacing, any BVP configuration produced a significant increase in the maximal LV diastolic pressure rise (LVdP/dTMax) (a median relative increase of 28% [IQR: 8%-45%], 25% [IQR: 18%-46%], 36% [IQR: 18%-54%], and 38% [IQR: 28%-58%], respectively; all, P &lt; 0.001). MSP-Max but no other multisite BVP generated a significant increase of the maximal LVdP/dTMax than conventional BVP (P = 0.041). Increased LVdP/dTMax during MSP-Max was associated with greater LV diameter and lower LV ejection fraction, independently of the QRS width. Conclusions: The study shows the hemodynamic advantage of a novel dual-vein MSP-Max configuration that could be useful for CRT in patients with advanced LV remodeling. © 2023 American College of Cardiology Foundation

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30201 - Cardiac and Cardiovascular systems

Result continuities

  • Project

    <a href="/en/project/NV18-02-00080" target="_blank" >NV18-02-00080: Electrical activation of the left ventricular myocardium by application of modified epicardial triventricular system for cardiac resynchronization therapy of heart failure</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    JACC Clinical Electrophysiology

  • ISSN

    2405-500X

  • e-ISSN

    2405-5018

  • Volume of the periodical

    9

  • Issue of the periodical within the volume

    11

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    2329-2338

  • UT code for WoS article

    001129919900001

  • EID of the result in the Scopus database

    2-s2.0-85173188164