Early vascular damage in retinal microcirculation in arterial hypertension: the Czech post-MONICA study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00084562" target="_blank" >RIV/00023001:_____/24:00084562 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11140/24:10476874 RIV/00064190:_____/24:10001069 RIV/00216208:11110/24:10476874

Result on the web

<a href="https://journals.lww.com/jhypertension/fulltext/2024/03000/early_vascular_damage_in_retinal_microcirculation.21.aspx" target="_blank" >https://journals.lww.com/jhypertension/fulltext/2024/03000/early_vascular_damage_in_retinal_microcirculation.21.aspx</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/HJH.0000000000003637" target="_blank" >10.1097/HJH.0000000000003637</a>

Result language

angličtina

Original language name

Early vascular damage in retinal microcirculation in arterial hypertension: the Czech post-MONICA study

Original language description

Retinal microcirculation reflects retinal perfusion abnormalities and retinal arterial structural changes at relatively early stages of various cardiovascular diseases. Wall-to-lumen ratio (WLR) may represent the earliest step in hypertension-mediated organ damage. Our objective was to compare functional and structural parameters of retinal microcirculation in a randomly selected urban population sample, in hypertensive and normotensive individuals. Design and method: A total of 398 randomly selected individuals from an urban population aged 25-65 years, residing in Pilsen, Czech Republic, were screened for major cardiovascular risk factors. Retinal microcirculation was assessed using scanning laser Doppler flowmetry, with data evaluable in 343 patients. Complete data were available for 342 individuals divided into four groups based on blood pressure and control status of hypertension: normotensive individuals (n = 213), treated controlled hypertensive individuals (n = 30), treated uncontrolled hypertensive individuals (n = 26), and newly detected/untreated hypertensive individuals (n = 73). Results: There was a tendency to higher wall thickness in treated but uncontrolled hypertensive patients (compared to normotensive and treated controlled hypertensive individuals). WLR was significantly increased in treated but uncontrolled hypertensive patients as well as in individuals with newly detected thus untreated hypertension or in patients with known but untreated hypertension. There was no difference in WLR in treated, controlled hypertensive patients compared with normotensive individuals. Conclusion: Our results show that an increased WLR, reflecting early vascular damage, was found in newly detected individuals with hypertension and in untreated hypertensive patients, reflecting early hypertension-mediated vascular damage. Early initiation of hypertension treatment may be warranted.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

<a href="/en/project/NV15-27109A" target="_blank" >NV15-27109A: Longitudinal trends in major cardiovascular risk factors and their predictive value in a population random sample, Czech post-MONICA study</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of hypertension

ISSN

0263-6352

e-ISSN

1473-5598

Volume of the periodical

42

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

557-563

UT code for WoS article

001153954000001

EID of the result in the Scopus database

2-s2.0-85184137356