Reference values of retinal microcirculation parameters derived from a population random sample
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00080628" target="_blank" >RIV/00023001:_____/21:00080628 - isvavai.cz</a>
Alternative codes found
RIV/00064190:_____/21:N0000085 RIV/00216208:11110/21:10427333 RIV/00216208:11140/21:10427333
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S0026286220301771?token=8782CA605B3CAD6111132A5A8FB4301F744EBA0CD8DE5CDE2441BD61EDF8AEFD8292F303938D2DD1D254AC8F6A69C1ED" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0026286220301771?token=8782CA605B3CAD6111132A5A8FB4301F744EBA0CD8DE5CDE2441BD61EDF8AEFD8292F303938D2DD1D254AC8F6A69C1ED</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mvr.2020.104117" target="_blank" >10.1016/j.mvr.2020.104117</a>
Alternative languages
Result language
angličtina
Original language name
Reference values of retinal microcirculation parameters derived from a population random sample
Original language description
Retinal microcirculation reflects retinal perfusion abnormalities and retinal arterial structural changes at relatively early stages of various cardiovascular diseases. Our objective has been to establish reference values for major functional and structural parameters of retinal microcirculation in a randomly selected urban population sample. A total of 398 randomly selected individuals from an urban population aged 25 to 65 years, resident in Pilsen, Czech Republic, were screened for major cardiovascular risk factors. Retinal microcirculation was assessed using scanning laser Doppler flowmetry (SLDF), with data evaluable in 343 patients. Of this number, complete data were available for 256 individuals free from manifest cardiovascular disease, diabetes and drug treatment for hypertension and/or dyslipidemia, constituting the reference value population. Juxtapapillary retinal capillary blood flow has increased significantly with age whereas vessel and luminal diameters have decreased. No sex differences in retinal microcirculation parameters have been found. Therefore, reference values for retinal microcirculation parameters have been established by age groups. Unattended automated office systolic BP, after adjusting for age, correlated significantly with wall-to-lumen ratio (WLR) and wall thickness (WT). Moreover, after adjusting for age and mean BP, a positive relationship has been found between carotid femoral pulse wave velocity and WT, WLR and wall cross-sectional area, indicating the interaction between micro- and macro-vasculature. In conclusion, our study is the first to provide reference values of retinal microcirculation parameters in a random Caucasian population sample. Our results have shown that, at the population level, the first structural changes in retinal microcirculation are those in lumen diameters. Of note, a close relationship between BP and vascular remodeling of retinal arterioles and between aortic stiffness and WLR of retinal arterioles suggests an interaction between micro- and macro-vasculature. © 2020 Elsevier Inc.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/NV15-27109A" target="_blank" >NV15-27109A: Longitudinal trends in major cardiovascular risk factors and their predictive value in a population random sample, Czech post-MONICA study</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Microvascular research
ISSN
0026-2862
e-ISSN
—
Volume of the periodical
134
Issue of the periodical within the volume
March
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
"art. no. 104117"
UT code for WoS article
000613199800014
EID of the result in the Scopus database
2-s2.0-85097053047