Hypertrophic remodelling of retinal arterioles in patients with congestive heart failure
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F21%3AN0000079" target="_blank" >RIV/00064190:_____/21:N0000079 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10428032
Result on the web
<a href="http://dx.doi.org/10.1002/ehf2.13334" target="_blank" >http://dx.doi.org/10.1002/ehf2.13334</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ehf2.13334" target="_blank" >10.1002/ehf2.13334</a>
Alternative languages
Result language
angličtina
Original language name
Hypertrophic remodelling of retinal arterioles in patients with congestive heart failure
Original language description
Aims Analysis of microvascular parameters in the retinal circulation-known to reflect those in the systemic circulation-allows us to differentiate between eutrophic and hypertrophic remodelling of small arteries. This study aimed to examine microvascular changes in patients with congestive heart failure (CHF) and reduced as well as mid-range ejection fraction. Methods and results Forty subjects with CHF underwent measurement of retinal capillary flow (RCF), wall-to-lumen ratio (WLR), vessel and lumen diameter, wall thickness, and wall cross-sectional area (WCSA) of retinal arterioles of the right eye by scanning laser Doppler flowmetry (SLDF). Applying a matched pair approach, we compared this group with reference values of age-matched controls from a random sample in the population of Pilsen, Czech Republic. There was no significant difference in RCF and WLR between the groups (RCF: P = 0.513; WLR: P = 0.106). In contrast, wall thickness and WCSA, indicators of hypertrophic remodelling, were higher in CHF subjects (WT: 15.0 +/- 4.2 vs. 12.7 +/- 4.2 mu m, P = 0.021; WCSA: 4437.6 +/- 1314.5 vs. 3615.9 +/- 1567.8 mu m(2), P = 0.014). Similarly, vessel (109.4 +/- 11.1 vs. 100.5 +/- 14.4 mu m, P = 0.002) and lumen diameter (79.0 +/- 7.9 vs. 75.2 +/- 8.5 mu m, P = 0.009) were increased in CHF. Conclusions In CHF subjects, we observed hypertrophic remodelling of retinal arterioles indicative of similar changes of small resistance arteries in the systemic circulation. Microvascular structure and function assessed by SLDF may thereby represent a useful, non-invasive method for monitoring of microvascular damage in patients with CHF and may offer innovative treatment targets for new CHF therapies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/NV15-27109A" target="_blank" >NV15-27109A: Longitudinal trends in major cardiovascular risk factors and their predictive value in a population random sample, Czech post-MONICA study</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ESC HEART FAILURE
ISSN
2055-5822
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
1892-1900
UT code for WoS article
000634928000001
EID of the result in the Scopus database
2-s2.0-85103429578