Mechanical regulation of mitochondrial morphodynamics in cancer cells by extracellular microenvironment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00084740" target="_blank" >RIV/00023001:_____/24:00084740 - isvavai.cz</a>

Alternative codes found

RIV/68378271:_____/24:00587163

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S2666534424000060?pes=vor" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2666534424000060?pes=vor</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bbiosy.2024.100093" target="_blank" >10.1016/j.bbiosy.2024.100093</a>

Result language

angličtina

Original language name

Mechanical regulation of mitochondrial morphodynamics in cancer cells by extracellular microenvironment

Original language description

Recently, it has been recognized that physical abnormalities (e.g. elevated solid stress, elevated interstitial fluid pressure, increased stiffness) are associated with tumor progression and development. Additionally, these mechanical forces originating from tumor cell environment through mechanotransduction pathways can affect metabolism. On the other hand, mitochondria are well-known as bioenergetic, biosynthetic, and signaling organelles crucial for sensing stress and facilitating cellular adaptation to the environment and physical stimuli. Disruptions in mitochondrial dynamics and function have been found to play a role in the initiation and advancement of cancer. Consequently, it is logical to hypothesize that mitochondria dynamics subjected to physical cues may play a pivotal role in mediating tumorigenesis. Recently mitochondrial biogenesis and turnover, fission and fusion dynamics was linked to mechanotransduction in cancer. However, how cancer cell mechanics and mitochondria functions are connected, still remain poorly understood. Here, we discuss recent studies that link mechanical stimuli exerted by the tumor cell environment and mitochondria dynamics and functions. This interplay between mechanics and mitochondria functions may shed light on how mitochondria regulate tumorigenesis.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/GA22-18634S" target="_blank" >GA22-18634S: Mechanical Regulation of Mitochondria Function and Glycolysis in Liver Cancer Cells</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomaterials and Biosystems

ISSN

2666-5344

e-ISSN

2666-5344

Volume of the periodical

14

Issue of the periodical within the volume

March 24

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

"art. no. 100093"

UT code for WoS article

—

EID of the result in the Scopus database

2-s2.0-85188991930