Mechanical regulation of mitochondrial morphodynamics in cancer cells by extracellular microenvironment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F24%3A00587163" target="_blank" >RIV/68378271:_____/24:00587163 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/24:00084740

Result on the web

<a href="https://hdl.handle.net/11104/0354436" target="_blank" >https://hdl.handle.net/11104/0354436</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bbiosy.2024.100093" target="_blank" >10.1016/j.bbiosy.2024.100093</a>

Result language

angličtina

Original language name

Mechanical regulation of mitochondrial morphodynamics in cancer cells by extracellular microenvironment

Original language description

Recently, it has been recognized that physical abnormalities (e.g. elevated solid stress, elevated interstitial fluid pressure, increased stiffness) are associated with tumor progression and development. Mitochondria are well-known as bioenergetic, biosynthetic, and signaling organelles crucial for sensing stress and facilitating cellular adaptation to the environment and physical stimuli. Consequently, it is logical to hypothesize that mitochondria dynamics subjected to physical cues may play a pivotal role in mediating tumorigenesis. However, how cancer cell mechanics and mitochondria functions are connected, still remain poorly understood. Here, we discuss recent studies that link mechanical stimuli exerted by the tumor cell environment and mitochondria dynamics and functions. This interplay between mechanics and mitochondria functions may shed light on how mitochondria regulate tumorigenesis.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

—

OECD FORD branch

10610 - Biophysics

Project

<a href="/en/project/GA22-18634S" target="_blank" >GA22-18634S: Mechanical Regulation of Mitochondria Function and Glycolysis in Liver Cancer Cells</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomaterials and Biosystems

ISSN

2666-5344

e-ISSN

—

Volume of the periodical

14

Issue of the periodical within the volume

June

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

100093

UT code for WoS article

—

EID of the result in the Scopus database

2-s2.0-85188991930