Mechanical regulation of mitochondrial dynamics and function in a 3D-engineered liver tumor microenvironment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F23%3A00572095" target="_blank" >RIV/68378041:_____/23:00572095 - isvavai.cz</a>
Alternative codes found
RIV/68378271:_____/23:00572095 RIV/00023001:_____/23:00083939
Result on the web
<a href="https://hdl.handle.net/11104/0342923" target="_blank" >https://hdl.handle.net/11104/0342923</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsbiomaterials.2c01518" target="_blank" >10.1021/acsbiomaterials.2c01518</a>
Alternative languages
Result language
angličtina
Original language name
Mechanical regulation of mitochondrial dynamics and function in a 3D-engineered liver tumor microenvironment
Original language description
It has become evident that physical stimuli of the cellular microenvironment transmit mechanical cues regulating key cellular functions, such as proliferation, migration, and malignant transformation. Accumulating evidence suggests that tumor cells face variable mechanical stimuli that may induce metabolic rewiring of tumor cells. We therefore designed soft 3D collagen scaffolds mimicking a pathological mechanical environment to decipher how liver tumor cells would adapt their metabolic activity to physical stimuli of the cellular microenvironment. Here, we report that the soft 3D microenvironment upregulates the glycolysis of HepG2 and Alexander cells. Both cell lines adapt their mitochondrial activity and function under growth in the soft 3D microenvironment.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
<a href="/en/project/GA22-18634S" target="_blank" >GA22-18634S: Mechanical Regulation of Mitochondria Function and Glycolysis in Liver Cancer Cells</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS BIOMATERIALS SCIENCE & ENGINEERING
ISSN
2373-9878
e-ISSN
2373-9878
Volume of the periodical
9
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
18
Pages from-to
2408-2425
UT code for WoS article
000972147400001
EID of the result in the Scopus database
2-s2.0-85151914668