Hepatic tumor cell morphology plasticity under physical constraints in 3D cultures driven by YAP-mTOR axis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F20%3A00537345" target="_blank" >RIV/61388955:_____/20:00537345 - isvavai.cz</a>
Alternative codes found
RIV/68378271:_____/20:00537345 RIV/00023001:_____/20:00080458 RIV/68378041:_____/20:00553160
Result on the web
<a href="http://hdl.handle.net/11104/0315072" target="_blank" >http://hdl.handle.net/11104/0315072</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ph13120430" target="_blank" >10.3390/ph13120430</a>
Alternative languages
Result language
angličtina
Original language name
Hepatic tumor cell morphology plasticity under physical constraints in 3D cultures driven by YAP-mTOR axis
Original language description
Recent studies undoubtedly show that the mammalian target of rapamycin (mTOR) and the Hippo–Yes-associated protein 1 (YAP) pathways are important mediators of mechanical cues. The crosstalk between these pathways as well as de-regulation of their signaling has been implicated in multiple tumor types, including liver tumors. Additionally, physical cues from 3D microenvironments have been identified to alter gene expression and di erentiation of di erent cell lineages. However, it remains incompletely understood how physical constraints originated in 3D cultures a ect cell plasticity and what the key mediators are of such process. In this work, we use collagen sca olds as a model of a soft 3D microenvironment to alter cellular size and study the mechanotransduction that regulates that process.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
<a href="/en/project/LTC19040" target="_blank" >LTC19040: Advanced physical methods in hepatotoxicity studies</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmaceuticals
ISSN
1424-8247
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
12
Country of publishing house
CH - SWITZERLAND
Number of pages
25
Pages from-to
1-25
UT code for WoS article
000602349300001
EID of the result in the Scopus database
2-s2.0-85097084397