TGF?: A player on multiple fronts in the tumor microenvironment

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F14%3A00436407" target="_blank" >RIV/61388971:_____/14:00436407 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
TGF?: A player on multiple fronts in the tumor microenvironment
Original language description
The physiological functions of transforming growth factor (TGF)-? in cell signaling include regulation of developmental processes and cell growth. Tumor cells very often display altered regulation of the TGF? signaling pathway, either by defects in TGF?itself or in downstream components of the pathway. TGF? can play a dual role in tumorigenesis, i.e. it can be either tumor-suppressive or tumor-promoting. TGF? suppresses the growth of tumor cells; however, in advanced tumors, it is associated with induction of progression, resulting in poor prognosis for patients. The TGF? negative regulation of cytotoxic cell function, together with the promotion of T-regulatory cell maturation, impairs anti-tumor responses. Recent studies have elucidated new roles for TGF? signaling in the tumor microenvironment. Abrogation of proper signaling induces epithelial-to-mesenchymal transition with pro-metastatic functions, resulting in cancer progression. Thus, TGF? signaling in the tumor microenvironment
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
<a href="/en/project/IAA500200917" target="_blank" >IAA500200917: Genetics and immunity in early stages of colorectal adenocarcinoma: inflammatory environment inconventional vs germ-free animal models, and in human samples</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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