Efficacy and safety of focal pulsed-field ablation for ventricular arrhythmias: two-centre experience
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00084949" target="_blank" >RIV/00023001:_____/24:00084949 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12110/24:43908587
Result on the web
<a href="https://academic.oup.com/europace/article/26/7/euae192/7710820?login=true" target="_blank" >https://academic.oup.com/europace/article/26/7/euae192/7710820?login=true</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/europace/euae192" target="_blank" >10.1093/europace/euae192</a>
Alternative languages
Result language
angličtina
Original language name
Efficacy and safety of focal pulsed-field ablation for ventricular arrhythmias: two-centre experience
Original language description
Aims A pulsed electric field (PF) energy source is a novel potential option for catheter ablation of ventricular arrhythmias (VAs) as it can create deeper lesions, particularly in scarred tissue. However, very limited data exist on its efficacy and safety. This prospective observational study reports the initial experience with VA ablation using focal PF.Methods and results The study population consisted of 44 patients (16 women, aged 61 +/- 14years) with either frequent ventricular premature complexes (VPCs, 48%) or scar-related ventricular tachycardia (VT, 52%). Ablation was performed using an irrigated 4 mm tip catheter and a commercially available PF generator. On average, 16 +/- 15 PF applications (25 A) were delivered per patient. Acute success was achieved in 84% of patients as assessed by elimination of VPC or reaching non-inducibility of VT. In three cases (7%), a transient conduction system block was observed during PF applications remotely from the septum. Root analysis revealed that this event was caused by current leakage from the proximal shaft electrodes in contact with the basal interventricular septum. Acute elimination of VPC was achieved in 81% patients and non-inducibility of VT in 83% patients. At the 3-month follow-up, persistent suppression of the VPC was confirmed on Holter monitoring in 81% patients. In the VT group, the mean follow-up was 116 +/- 75 days and a total of 52% patients remained free of any VA.Conclusion Pulsed electric field catheter ablation of a broad spectrum of VA is feasible with acute high efficacy; however, the short-term follow-up is less satisfactory for patients with scar-related VT. Graphical Abstract
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/LX22NPO5104" target="_blank" >LX22NPO5104: National Institute for Research of Metabolic and Cardiovascular Diseases</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Europace
ISSN
1099-5129
e-ISSN
1532-2092
Volume of the periodical
26
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
"art. no. euae192"
UT code for WoS article
001274847000002
EID of the result in the Scopus database
2-s2.0-85199689929