A tagging polymorphism in fat mass and obesity-associated (FTO) gene is associated with sepsis status in children

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00084980" target="_blank" >RIV/00023001:_____/24:00084980 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/24:00136129 RIV/00216208:11110/24:10479950 RIV/65269705:_____/24:00079717

Result on the web

<a href="https://sciendo.com/article/10.2478/rjim-2024-0008" target="_blank" >https://sciendo.com/article/10.2478/rjim-2024-0008</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/rjim-2024-0008" target="_blank" >10.2478/rjim-2024-0008</a>

Result language

angličtina

Original language name

A tagging polymorphism in fat mass and obesity-associated (FTO) gene is associated with sepsis status in children

Original language description

Introduction Sepsis is one of the most common causes of death in patients admitted to intensive care units (ICUs). The development of sepsis is significantly influenced by genetic predisposition. In this study, we highlight a potential association between a variant of the fat mass and obesity-associated (FTO) gene and risk of sepsis in children and adolescents. Methods We investigated a first-intron tagging FTO polymorphism (rs17817449) by comparing a severe condition (SC) group, comprising 598 paediatric patients (ages 0-19 years) admitted to an ICU with fever, systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome (MODS), with a control group consisting of 616 healthy young adults. Results We observed a lower prevalence (p &lt; 0.01; OR = 0.59, 95% CI = 0.39-0.87) of the FTO TT genotype in febrile and SIRS patients compared to patients with severe illness. There was a borderline trend towards a lower prevalence of the FTO TT genotype in the control group compared to the SC group (p &lt; 0.09, OR = 0.81, 95% CI = 0.62-1.06). Conclusions Our findings suggest that rs17817449, a common FTO polymorphism, may be a predictor of sepsis in paediatric patients, and that higher body weight is protective against this clinical complication.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30218 - General and internal medicine

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Romanian Journal of Internal Medicine

ISSN

1582-3296

e-ISSN

2501-062X

Volume of the periodical

62

Issue of the periodical within the volume

3

Country of publishing house

PL - POLAND

Number of pages

18

Pages from-to

279-285

UT code for WoS article

001181323600001

EID of the result in the Scopus database

2-s2.0-85202791515