Cationic fluorinated micelles for cell labeling and 19F-MR imaging
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00085083" target="_blank" >RIV/00023001:_____/24:00085083 - isvavai.cz</a>
Alternative codes found
RIV/46747885:24530/24:00013363 RIV/00216208:11110/24:10485795 RIV/00216208:11120/24:43927591 RIV/00216208:11310/24:10485795
Result on the web
<a href="https://www.nature.com/articles/s41598-024-73511-8" target="_blank" >https://www.nature.com/articles/s41598-024-73511-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-024-73511-8" target="_blank" >10.1038/s41598-024-73511-8</a>
Alternative languages
Result language
angličtina
Original language name
Cationic fluorinated micelles for cell labeling and 19F-MR imaging
Original language description
Magnetic resonance imaging (MRI) relies on appropriate contrast agents, especially for visualizing transplanted cells within host tissue. In recent years, compounds containing fluorine-19 have gained significant attention as MRI probe, particularly in dual 1H/19F-MR imaging. However, various factors affecting probe sensitivity, such as fluorine content and the equivalency of fluorine atoms, must be considered. In this study, we synthesized fluorinated micelles with adjustable surface positive charge density and investigated their physicochemical properties and MRI efficacy in phantoms and labeled cells. While the micelles exhibited clear signals in 19F-MR spectra and imaging, the concentrations required for MRI visualization of labeled cells were relatively high, adversely affecting cell viability. Despite their favourable physicochemical properties, achieving higher labeling rates without compromising cell viability during labeling remains a challenge for potential in vivo applications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific reports
ISSN
2045-2322
e-ISSN
2045-2322
Volume of the periodical
14
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
"art. no. 22613"
UT code for WoS article
001326080400054
EID of the result in the Scopus database
2-s2.0-85205446534