Vascular Grafts Derived from Decellularized Tissues Modified with 3D Bioprinting
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00085207" target="_blank" >RIV/00023001:_____/24:00085207 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/chapter/10.1007/978-3-031-62520-6_45" target="_blank" >https://link.springer.com/chapter/10.1007/978-3-031-62520-6_45</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-031-62520-6_45" target="_blank" >10.1007/978-3-031-62520-6_45</a>
Alternative languages
Result language
angličtina
Original language name
Vascular Grafts Derived from Decellularized Tissues Modified with 3D Bioprinting
Original language description
Cardiovascular surgery lacks suitable biomaterials for bypass surgery and patch repair. Currently available grafts for bypass surgery possess many shortcomings. In this study we are aiming to prepare vascular grafts and patches based on decellularized and lyophilized matrices (pericardium and vessels) with further recolonization with adipose derived stromal or Wharton’s jelly stromal cells. Decellularization was held in a custom-built automated system allowing cyclic change of decellularization agents and cleaning water, maintaining a reproducible process. To ensure homogenous recolonization of prepared substrates the 3D bioprinting and microextrusion method was utilized. Planar tissues were recolonized using 3D bioprinting methods. Porcine collagen with incorporated cells was used. Then to coat the inner lumen of tubular tissue microextrusion method was created. It uses special microcannulas where collagen with cells was extruded, leaving inner lumen homogeneously coated. Prepared planar patches and tubular grafts were then implanted into pigs for one month observation. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30212 - Surgery
Result continuities
Project
<a href="/en/project/NV19-02-00068" target="_blank" >NV19-02-00068: Bioartificial cardiovascular patches and vessels from porcine collagen reinforced with nano/microfibers using stem cells and dynamic culture</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Advances in Digital Health and Medical Bioengineering : IFMBE Proceedings
ISBN
978-3-031-62519-0
Number of pages of the result
8
Pages from-to
406-413
Number of pages of the book
696
Publisher name
Springer
Place of publication
Cham
UT code for WoS chapter
001326809000045