Vascular Grafts Derived from Decellularized Tissues Modified with 3D Bioprinting

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985891%3A_____%2F24%3A00604266" target="_blank" >RIV/67985891:_____/24:00604266 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1007/978-3-031-62520-6_45" target="_blank" >https://doi.org/10.1007/978-3-031-62520-6_45</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-031-62520-6_45" target="_blank" >10.1007/978-3-031-62520-6_45</a>

Result language
angličtina
Original language name
Vascular Grafts Derived from Decellularized Tissues Modified with 3D Bioprinting
Original language description
Cardiovascular surgery lacks suitable biomaterials for bypass surgery and patch repair. Currently available grafts for bypass surgery possess many shortcomings. In this study we are aiming to prepare vascular grafts and patches based on decellularized and lyophilized matrices (pericardium and vessels) with further recolonization with adipose derived stromal or Wharton's jelly stromal cells. Decellularization was held in a custom-built automated system allowing cyclic change of decellularization agents and cleaning water, maintaining a reproducible process. To ensure homogenous recolonization of prepared substrates the 3D bioprinting and microextrusion method was utilized. Planar tissues were recolonized using 3D bioprinting methods. Porcine collagen with incorporated cells was used. Then to coat the inner lumen of tubular tissue microextrusion method was created. It uses special microcannulas where collagen with cells was extruded, leaving inner lumen homogeneously coated. Prepared planar patches and tubular grafts were then implanted into pigs for one month observation.
Czech name
—
Czech description
—

Project
<a href="/en/project/NV19-02-00068" target="_blank" >NV19-02-00068: Bioartificial cardiovascular patches and vessels from porcine collagen reinforced with nano/microfibers using stem cells and dynamic culture</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Advances in digital health and medical bioengineering, VOL 2, EHB-2023
ISBN
978-3-031-62520-6
ISSN
1680-0737
e-ISSN
—
Number of pages
8
Pages from-to
406-413
Publisher name
Springer
Place of publication
Cham
Event location
Bucharest
Event date
Nov 9, 2023
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
001326809000045

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