Prediction of major intravascular hemolysis during pulsed electric field ablation of atrial fibrillation using a pentaspline catheter
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00085273" target="_blank" >RIV/00023001:_____/24:00085273 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/24:10488429
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/jce.16468" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1111/jce.16468</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jce.16468" target="_blank" >10.1111/jce.16468</a>
Alternative languages
Result language
angličtina
Original language name
Prediction of major intravascular hemolysis during pulsed electric field ablation of atrial fibrillation using a pentaspline catheter
Original language description
Introduction: Pulsed electric field (PEF) has emerged as a promising energy sourcefor catheter ablation of atrial fibrillation (AF). However, data regarding the in‐vivoeffect of PEF energy on erythrocytes during AF ablation procedures are scarce. Thisstudy aimed to quantify the impact of PEF energy on erythrocyte damage during AFablation by assessing specific hemolytic biomarkers.Methods: A total of 60 patients (age: 68 years, males: 72%, serum creatinine:91 µmol/L) with AF underwent catheter ablation of AF using PEF energy deliveredby a multipolar pentaspline Farawave catheter (Farapulse, Boston Scientific, Inc.).Ablation beyond pulmonary vein isolation was performed at the operator's discre-tion. Peripheral venous blood was sampled for assessing the plasma levels of freehemoglobin (fHb), direct (conjugated) bilirubin, lactate dehydrogenase (LDH), andcreatinine before, immediately after the ablation, and on the next day.Results: Following the PEF ablation with duration of [median (interquartile range)] 75(58, 95) min, with 74 (52, 92) applications and PVI only in 27% of patients, fHb, LDH,and direct bilirubin significantly increased, from 40 (18, 65) to 493 (327, 848) mg/L,from 3.1 (2.6, 3.6) to 6.8 (5.0, 7.9) µkat/L, and from 12 (9, 17) to 28 (16, 44) µmol/L,respectively (all p < .0001). A strong linear correlation was found between the peakfHb and the number of PEF applications (R = 0.81, p < .001). The major hemolysis(defined as fHb >500 mg/L) was predicted by the number of PEF applications withthe corresponding area under the receiver operating characteristic curve of 0.934.The optimum cut‐off value of >74 PEF applications predicted the major hemolysiswith 89% sensitivity and 87% specificity.Conclusion: Catheter ablation of AF using PEF energy delivered from a pentasplinecatheter is associated with significant intravascular hemolysis. More than 74 PEF ap-plications frequently resulted in major hemolysis. However, the critical amount of PEFenergy that may cause kidney injury in susceptible patients remains to be investigated.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/LX22NPO5104" target="_blank" >LX22NPO5104: National Institute for Research of Metabolic and Cardiovascular Diseases</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of cardiovascular electrophysiology
ISSN
1045-3873
e-ISSN
1540-8167
Volume of the periodical
35
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
2405-2410
UT code for WoS article
001336507100001
EID of the result in the Scopus database
2-s2.0-85206211740