Eicosanoids in Coronary Sinus Correlate with NT-proBNP in Heart Failure with Reduced Ejection Fraction Indicated to Resynchronization Therapy: Insights from Eicosanoids in Human Heart Failure Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F25%3A00085528" target="_blank" >RIV/00023001:_____/25:00085528 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/25:10494846 RIV/00064203:_____/25:10494846
Result on the web
<a href="https://link.springer.com/content/pdf/10.1007/s44411-025-00031-w.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007/s44411-025-00031-w.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s44411-025-00031-w" target="_blank" >10.1007/s44411-025-00031-w</a>
Alternative languages
Result language
angličtina
Original language name
Eicosanoids in Coronary Sinus Correlate with NT-proBNP in Heart Failure with Reduced Ejection Fraction Indicated to Resynchronization Therapy: Insights from Eicosanoids in Human Heart Failure Study
Original language description
IntroductionThe diagnostic potential of eicosanoids, metabolites of arachidonic acid with cardio-renal activity, in chronic heart failure with reduced ejection fraction (HFrEF) remains unclear. The aim was to investigate levels of eicosanoids in different body compartments and their relation to natriuretic peptides.Material and methodsEleven HFrEF patients indicated to cardiac resynchronization therapy (CRT) were enrolled to measure 14,15-epoxyeicosatrienoic acid (14,15-EET), 14,15-dihydroxyicosatrienoic acid (14,15-DHET) and N-terminal pro B-type natriuretic peptide (NT-proBNP) levels from venous, arterial, and coronary sinus (CS) blood samples.ResultsIn CS, NT-proBNP negatively correlated with plasmatic 14,15-EET (r = - 0.63, p = 0.03) and positively with the DHET/EET ratio (r = 0.73, p = 0.02). This correlation was not found in the other compartments. Plasmatic 14,15-EET nor 14,15-DHET levels in measured compartments did not differ statistically (p = 0.21, p = 0,64, respectively). In individual patients, the levels of both eicosanoids correlated across all compartments. Peripheral plasma 14,15-EET levels in controls were lower compared to HFrEF patients.ConclusionsPeripheral venous eicosanoid (14,15-EET, 14,15-DHET) levels correlate and do not differ from arterial and CS levels in patients with HFrEF indicated to CRT. In CS, NT-proBNP negatively correlates with plasmatic 14,15-EET and positively with the DHET/EET ratio, an indirect measurement of soluble epoxide hydrolase (sEH) activity, suggesting an important role of eicosanoids and sEH in HFrEF pathophysiology.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/NU23J-02-00015" target="_blank" >NU23J-02-00015: New pharmacological approaches for the treatment of heart failure with reduced ejection fraction combined with chronic kidney disease.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bratislavské lekárske listy
ISSN
0006-9248
e-ISSN
1336-0345
Volume of the periodical
126
Issue of the periodical within the volume
2
Country of publishing house
SK - SLOVAKIA
Number of pages
7
Pages from-to
228-234
UT code for WoS article
001465540600011
EID of the result in the Scopus database
2-s2.0-85217772793