Evaluation of ceruloplasmin - a potential biomarker in chronic heart failure

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023884%3A_____%2F18%3A00007791" target="_blank" >RIV/00023884:_____/18:00007791 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.4172/2155-9880.1000601" target="_blank" >http://dx.doi.org/10.4172/2155-9880.1000601</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4172/2155-9880.1000601" target="_blank" >10.4172/2155-9880.1000601</a>

Result language

angličtina

Original language name

Evaluation of ceruloplasmin - a potential biomarker in chronic heart failure

Original language description

Background: Ceruloplasmin (Cp) is an acute phase protein with plasma copper binding properties and is involved in inflammatory processes and oxidative stress. Cp may play a role in the pathophysiology of heart failure. Study objective: to analyse relation of Cp with disease severity in patients with chronic stable heart failure as assessed by clinical and laboratory parameters Patients and methods: Serum levels of Cp, NT-proBNP and other biochemical parameters were analysed in 164 consecutive patients with chronic stable heart failure (CHF group). Consecutive 64 patients with arterial hypertension (AH group) without heart failure served as a control group. Results: Mean Cp level in CHF group was 230 mg/l and 200 mg/l in AH group (p < 0.001), mean NT-proBNP was 1843 pg/ml in CHF and 139 pg/ml AH (p < 0.001). Cp correlated with NT-proBNP in HF (r = 0.323, p < 0.001) in CHF group significantly and in AH group not significantly (r = 0.222, p = 0.08). Cp correlated significantly with total bilirubin (r = 0.213, p = 0.0067) and with albumin (inverse correlation r = - 0.273, p = 0.0005). Cp level correlated with functional class NYHA (r = 0.230, p = 0.0034) and LV EF (inverse correlation – 0.237, p = 0.0025) too. Cp correlated in both groups (n = 228) with NT-proBNP significantly (r = 0.349, p < 0.0001). Conclusion: Cp in patients with stable CHF correlates with disease severity as assessed by the level of NT-proBNP, functional class NYHA, LV EF, bilirubin and albumin.

Czech name

—

Czech description

—

Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Clinical & Experimental Cardiology

ISSN

2155-9880

e-ISSN

—

Volume of the periodical

9

Issue of the periodical within the volume

8

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

—

UT code for WoS article

—

EID of the result in the Scopus database

—