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Role of biomarkers of cardiac remodeling, myofibrosis, and inflammation in assessment of disease severity in euvolemic patients with chronic stable heart failure

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00532501" target="_blank" >RIV/61388971:_____/20:00532501 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11120/20:43920395 RIV/00023884:_____/20:00008628

  • Result on the web

    <a href="https://journals.sagepub.com/doi/10.1177/0300060520947869" target="_blank" >https://journals.sagepub.com/doi/10.1177/0300060520947869</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1177/0300060520947869" target="_blank" >10.1177/0300060520947869</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Role of biomarkers of cardiac remodeling, myofibrosis, and inflammation in assessment of disease severity in euvolemic patients with chronic stable heart failure

  • Original language description

    Objective This study aimed to determine the importance of biomarkers of chronic heart failure (CHF) for assessing disease severity in euvolemic stable patients. Patients and methods N-terminal pro-B-type natriuretic peptide (NT-proBNP), growth differentiation factor (GDF)-15, galectin-3, cystatin-C, soluble suppression of tumorigenicity 2 (sST2), tissue type inhibitor of matrix metalloproteinase (TIMP)-1, and ceruloplasmin levels were measured in euvolemic patients with stable CHF. Severity of CHF was defined by echocardiographic and biochemical parameters. Results In 160 patients (123 men and 37 women, mean age: 65.8 +/- 12.2 years), we found strong associations between NT-proBNP and bilirubin levels (r = 0.434) and the estimated glomerular filtration rate (r = -0.321). GDF-15 and cystatin-C levels were significantly correlated with parameters of kidney function. In multivariable regression analysis, NT-proBNP levels were associated with the left ventricular ejection fraction and left ventricular end-systolic volume (coefficient of determination R-2 = 0.777). Additionally, GDF-15 levels were correlated with urea levels (R-2 = 0.742), and cystatin C levels were correlated with urea and bilirubin levels (R-2 = 0.732). Conclusion Besides NT-proBNP, GDF-15 and cystatin C are promising biomarkers for establishing the severity of disease in euvolemic patients with stable CHF.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10606 - Microbiology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of International Medical Research

  • ISSN

    0300-0605

  • e-ISSN

  • Volume of the periodical

    48

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    12

  • Pages from-to

    0300060520947869

  • UT code for WoS article

    000563407900001

  • EID of the result in the Scopus database

    2-s2.0-85089685823