Role of biomarkers of cardiac remodeling, myofibrosis, and inflammation in assessment of disease severity in euvolemic patients with chronic stable heart failure
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00532501" target="_blank" >RIV/61388971:_____/20:00532501 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/20:43920395 RIV/00023884:_____/20:00008628
Result on the web
<a href="https://journals.sagepub.com/doi/10.1177/0300060520947869" target="_blank" >https://journals.sagepub.com/doi/10.1177/0300060520947869</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/0300060520947869" target="_blank" >10.1177/0300060520947869</a>
Alternative languages
Result language
angličtina
Original language name
Role of biomarkers of cardiac remodeling, myofibrosis, and inflammation in assessment of disease severity in euvolemic patients with chronic stable heart failure
Original language description
Objective This study aimed to determine the importance of biomarkers of chronic heart failure (CHF) for assessing disease severity in euvolemic stable patients. Patients and methods N-terminal pro-B-type natriuretic peptide (NT-proBNP), growth differentiation factor (GDF)-15, galectin-3, cystatin-C, soluble suppression of tumorigenicity 2 (sST2), tissue type inhibitor of matrix metalloproteinase (TIMP)-1, and ceruloplasmin levels were measured in euvolemic patients with stable CHF. Severity of CHF was defined by echocardiographic and biochemical parameters. Results In 160 patients (123 men and 37 women, mean age: 65.8 +/- 12.2 years), we found strong associations between NT-proBNP and bilirubin levels (r = 0.434) and the estimated glomerular filtration rate (r = -0.321). GDF-15 and cystatin-C levels were significantly correlated with parameters of kidney function. In multivariable regression analysis, NT-proBNP levels were associated with the left ventricular ejection fraction and left ventricular end-systolic volume (coefficient of determination R-2 = 0.777). Additionally, GDF-15 levels were correlated with urea levels (R-2 = 0.742), and cystatin C levels were correlated with urea and bilirubin levels (R-2 = 0.732). Conclusion Besides NT-proBNP, GDF-15 and cystatin C are promising biomarkers for establishing the severity of disease in euvolemic patients with stable CHF.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of International Medical Research
ISSN
0300-0605
e-ISSN
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Volume of the periodical
48
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
0300060520947869
UT code for WoS article
000563407900001
EID of the result in the Scopus database
2-s2.0-85089685823