Perivascular adipocyte size is related to the lipid profile and inflammatory changes in a healthy population
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F25%3A00085631" target="_blank" >RIV/00023001:_____/25:00085631 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/25:10499092 RIV/00216208:11310/25:10499092
Result on the web
<a href="https://www.tandfonline.com/doi/epdf/10.1080/21623945.2025.2499500?needAccess=true" target="_blank" >https://www.tandfonline.com/doi/epdf/10.1080/21623945.2025.2499500?needAccess=true</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/21623945.2025.2499500" target="_blank" >10.1080/21623945.2025.2499500</a>
Alternative languages
Result language
angličtina
Original language name
Perivascular adipocyte size is related to the lipid profile and inflammatory changes in a healthy population
Original language description
Inflammatory changes in perivascular adipose tissue are associated with atherosclerotic lesions in the adjacent artery and can also be used as a marker in patient workup. While adipocyte size is known to be closely related to adipose tissue dysfunction and inflammation, it has not been widely studied in perivascular adipose tissue obtained from healthy human subjects without clinical atherosclerosis. In this cross-sectional study, we addressed this issue by measuring adipocyte size and defining its relationship to cardiovascular risk factors in a healthy cohort of living kidney donors. The presence of cardiovascular risk factors was established by a standardized questionnaire, clinical measurements and body composition analyses. Adipocyte size was measured in the perivascular depot. The proportions of various macrophage subtypes were determined by flow cytometry. To confirm the results, the proportion of CD68 + macrophages was additionally assessed by immunohistochemistry. A correlation and principal component analyses were performed to explore associations. Adipocyte size in perivascular adipose tissue correlated with markers of lipid metabolism, inflammation, and glucose metabolism. Further, the positive correlation with the pro-inflammatory subpopulation of macrophages suggests a strong local effect of perivascular adipose tissue. Perivascular adipocyte size was associated with cardiovascular risk factors and markers of inflammation in a healthy cohort of living kidney donors. This further supports the local role of adipose tissue dysfunction and inflammation in early atherosclerosis development and detection.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
<a href="/en/project/LX22NPO5104" target="_blank" >LX22NPO5104: National Institute for Research of Metabolic and Cardiovascular Diseases</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Adipocyte
ISSN
2162-3945
e-ISSN
2162-397X
Volume of the periodical
14
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
"art. no. 2499500"
UT code for WoS article
001493525400001
EID of the result in the Scopus database
2-s2.0-105005988412