Cellular mechanisms of medium-chain chlorinated paraffins toxicity: the effect of cellular lipid content
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F25%3A00085689" target="_blank" >RIV/00023001:_____/25:00085689 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22330/25:43931475
Result on the web
<a href="https://www.tandfonline.com/doi/epdf/10.1080/15376516.2025.2481909?needAccess=true" target="_blank" >https://www.tandfonline.com/doi/epdf/10.1080/15376516.2025.2481909?needAccess=true</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/15376516.2025.2481909" target="_blank" >10.1080/15376516.2025.2481909</a>
Alternative languages
Result language
angličtina
Original language name
Cellular mechanisms of medium-chain chlorinated paraffins toxicity: the effect of cellular lipid content
Original language description
Research on chlorinated paraffins (CPs) is growing, with accumulating evidence of CPs being present in biological matrices and animal tissues. However, their cellular-level impacts remain underexplored. This study investigates the effects of medium-chain CPs on adipose and liver cell models. The results show that CPs are more toxic at lower concentrations in 3T3-L1 preadipocytes than in adipocytes, suggesting that intracellular lipids may offer protection against these contaminants. However, neither simulated lipolysis in adipocytes nor lipogenesis in HepG2 hepatocytes revealed any lipid-dependent effects of CPs. CP exposure reduced heme oxygenase 1 expression, indicating a biological response to these contaminants. In a coculture model of adipocytes and macrophages, CP exposure influenced cell signaling, with lipid-rich adipocytes modulating macrophage immune responses. Our results demonstrate that medium-chain CPs accumulation in lipid-rich tissues does not significantly affect their toxic effects. However, it may influence cell signaling within adipose tissue.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Toxicology Mechanisms and Methods
ISSN
1537-6516
e-ISSN
1537-6524
Volume of the periodical
35
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
"655–667"
UT code for WoS article
001455451800001
EID of the result in the Scopus database
2-s2.0-105001982985