Selected Genetic Characteristics of the Vietnamese Minority Living in the Czech Republic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F25%3A00085789" target="_blank" >RIV/00023001:_____/25:00085789 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/25:10498446 RIV/00064165:_____/25:10498446

Result on the web

<a href="https://foliabiologica.lf1.cuni.cz/71/1/0001/#acknowledgements" target="_blank" >https://foliabiologica.lf1.cuni.cz/71/1/0001/#acknowledgements</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14712/fb2025071010001" target="_blank" >10.14712/fb2025071010001</a>

Result language

angličtina

Original language name

Selected Genetic Characteristics of the Vietnamese Minority Living in the Czech Republic

Original language description

The aim of this study was to analyse the allelic distribution of selected genes in the Czech and Vietnamese populations. We analysed samples from 94 Vietnamese volunteers and 2,859 Czech population-based subjects (2,559 from the Czechs post-MONICA and 300 volunteers from the South region of the Czech Republic). There were significant differences between the two populations for most, but not all, of the SNPs analysed. In particular, the prevalence of risk alleles in the analysed polymorphisms tended to be lower in the Vietnamese community compared to the Czech population, especially within the FTO (rs17817449; associated with obesity risk, P &lt; 0.0001), TCF7L2 (rs7903146; linked to type 2 diabetes, P &lt; 0.0001) and ADH1B (rs1229984; related to alcohol consumption, P &lt; 0.0001) genes. The genotype within the MCM6/LCT cluster (rs4988235) associated with lactase persistence was not present in the Vietnamese population. Slight genotype differences were detected for one HFE polymorphism (rs1799945 with P = 0.005; but not for rs1800562). Only the genotype frequencies within the MC4R and APOE genes were almost identical in both populations. We conclude that the Vietnamese population may have a lower genetic predisposition to the non-communicable diseases such as obesity or diabetes mellitus.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia biologica (Praha)

ISSN

0015-5500

e-ISSN

2533-7602

Volume of the periodical

71

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

1-7

UT code for WoS article

001481847100001

EID of the result in the Scopus database

2-s2.0-105004481391