Unlocking the resorption potential of cannabidiolic acid: A comprehensive in vitro and in vivo bioavailability study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F25%3A00085823" target="_blank" >RIV/00023001:_____/25:00085823 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22330/25:43932269

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0378517325009470?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0378517325009470?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijpharm.2025.126110" target="_blank" >10.1016/j.ijpharm.2025.126110</a>

Result language

angličtina

Original language name

Unlocking the resorption potential of cannabidiolic acid: A comprehensive in vitro and in vivo bioavailability study

Original language description

Phytocannabinoids, unique secondary metabolites of the plant Cannabis sativa L., are characterised by a wide spectrum of pharmacological activities and their use in medicine and food industry has increased exponentially in recent years. In this study, the bioavailability of 10 representatives of neutral cannabinoids and cannabinoid acids was evaluated using an in vitro model of Caco-2 cells, as well as in vivo using an inbred mouse model. In the context of a possible increase in bioavailability, the influence of matrix components associated with the &apos;cannabis synergy&apos; phenomenon was also investigated. The analysis of cannabinoids and non-cannabinoid matrix components was performed using a sensitive and validated method based on ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry (UHPLC-HRMS/MS). As a proof of concept for testing formulation effects on bioavailability, the most abundant cannabinoid and its corresponding acid (CBD and CBDA) were encapsulated in nanomicelles and the effect of the formulation was tested both in vitro and in vivo. The experiments showed that cannabidiolic acid (CBDA) had a significantly better bioavailability compared to cannabidiol (CBD), especially in the in vivo model (CBDA concentrations in mouse plasma were approximately two orders of magnitude higher than those of CBD under the same dosing conditions). These results demonstrate the great potential of CBDA as a previously overlooked and therapeutically underutilized substance.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

<a href="/en/project/GA22-20860S" target="_blank" >GA22-20860S: Anti-inflammatory properties of bioactive compounds isolated from Cannabis sativa L.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International journal of pharmaceutics

ISSN

0378-5173

e-ISSN

1873-3476

Volume of the periodical

684

Issue of the periodical within the volume

November 2025

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

11

Pages from-to

"art. no. 126110"

UT code for WoS article

001565870200001

EID of the result in the Scopus database

2-s2.0-105013981282