Supernatant versus exosomal urinary microRNAs. Two fractions with different outcomes in gynaecological cancers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023698%3A_____%2F16%3AN0000021" target="_blank" >RIV/00023698:_____/16:N0000021 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/16:00090478 RIV/00216208:11110/16:10325175 RIV/00216208:11120/16:43912495 RIV/65269705:_____/16:00065338 RIV/00064165:_____/16:10325175
Result on the web
<a href="http://dx.doi.org/10.4149/neo_2016_015" target="_blank" >http://dx.doi.org/10.4149/neo_2016_015</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/neo_2016_015" target="_blank" >10.4149/neo_2016_015</a>
Alternative languages
Result language
angličtina
Original language name
Supernatant versus exosomal urinary microRNAs. Two fractions with different outcomes in gynaecological cancers
Original language description
MicroRNAs (miRNAs) are key regulatory molecules implicated in fundamental cell processes. Recent investigations have been focused to investigate their diagnostic potential also in various body fluids. Plasma and serum are widely used for these purposes. Urinary miRNAs, as the easily available type of sample, have been explored particularly in urological diseases recently. However, we have shown previously that differential expression of urinary cell-free miRNAs may be observed also in gynaecological cancers, such as ovarian and endometrial cancers. In the present article, we focus on the differences in particular urine cell-free miRNA abundance among different samples including particularly ovarian and endometrial cancers and rare gynaecological diagnoses involved in the study. Using raw abundance miRNA expression data, we confirmed significant up-regulation of miR-92a in ovarian cancer, and significant down-regulation of miR-106b in endometrial cancers. As miR-21 appeared up-regulated in the endometrial cancer similarly as in the verification process, where also miR-106b resulted in significant down-regulation in ovarian cancer, these miRNAs may be good candidates for further evaluation as novel diagnostics.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FK - Gynaecology and obstetrics
OECD FORD branch
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Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neoplasma
ISSN
0028-2685
e-ISSN
—
Volume of the periodical
63
Issue of the periodical within the volume
1
Country of publishing house
SK - SLOVAKIA
Number of pages
12
Pages from-to
123-132
UT code for WoS article
000370305700015
EID of the result in the Scopus database
2-s2.0-84969673050