Impact of genomic risk factors on survival after haematopoietic stem cell transplantation for patients with acute leukaemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023698%3A_____%2F16%3AN0000023" target="_blank" >RIV/00023698:_____/16:N0000023 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/16:10333456 RIV/00216208:11120/16:43912496 RIV/00064203:_____/16:10333456
Result on the web
<a href="http://dx.doi.org/10.1111/iji.12295" target="_blank" >http://dx.doi.org/10.1111/iji.12295</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/iji.12295" target="_blank" >10.1111/iji.12295</a>
Alternative languages
Result language
angličtina
Original language name
Impact of genomic risk factors on survival after haematopoietic stem cell transplantation for patients with acute leukaemia
Original language description
The EBMT risk score is an established tool successfully used in the prognosis of survival post-HSCT and is applicable for a range of haematological disorders. One of its main advantages is that score generation involves summation of clinical parameters that are available pretransplant. However, the EBMT risk score is recognized as not being optimal. Previous analyses, involving patients with various diagnoses, have shown that non-HLA gene polymorphisms influence outcome after allogeneic HSCT. This study is novel as it focuses only on patients having acute leukaemia (N = 458) and attempts to demonstrate how non-HLA gene polymorphisms can be added to the EBMT risk score in a Cox regression model to improve prognostic ability for overall survival. The results of the study found that three genetic factors improved EBMT risk score.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—
Result continuities
Project
—
Continuities
R - Projekt Ramcoveho programu EK
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Immunogenetics
ISSN
1744-3121
e-ISSN
—
Volume of the periodical
43
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
404-412
UT code for WoS article
000393312700007
EID of the result in the Scopus database
2-s2.0-84995810988