Morphological and Functional Changes in the Vagina following Critical Lifespan Events in the Ewe
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023698%3A_____%2F19%3AN0000009" target="_blank" >RIV/00023698:_____/19:N0000009 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/19:43917508
Result on the web
<a href="https://doi.org/10.1159/000495348" target="_blank" >https://doi.org/10.1159/000495348</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1159/000495348" target="_blank" >10.1159/000495348</a>
Alternative languages
Result language
angličtina
Original language name
Morphological and Functional Changes in the Vagina following Critical Lifespan Events in the Ewe
Original language description
The ewe is increasingly being used as an animal model for pelvic floor disorders. The aim was to further characterize changes in the vaginal properties during its entire lifespan. METHODS: Vaginal tissues were collected at different stages of reproductive life (neonatal, prepubescence, nulliparous, primiparous, multiparous, and menopausal; GREATER-THAN OR EQUAL TO6 ewes/group). Vaginal size, as well as active and passive biomechanics, was measured. Microscopy included thickness of glycogen, epithelium, lamina propria and muscularis thickness, densities of collagen, elastin, smooth muscle, and nerves. RESULTS: Vaginal dimensions increase during adolescence, peak at reproductive levels, and decrease sharply after ovariectomy. One year after first delivery, the distal vagina gets more compliant, yet this is reversed later in life. The thickness of glycogen staining epithelial layers changed with puberty and menopause. The epithelium was markedly thicker after multiple deliveries. The thickness of lamina propria and muscularis increased in puberty and in nulliparous. Semi-quantitative collagen assessment demonstrated a lower collagen and higher elastin content after first and multiple deliveries. CONCLUSION: The changes in the ovine vaginal wall during representative moments of her lifespan parallel those observed in women.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30214 - Obstetrics and gynaecology
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Gynecologic and Obstetric Investigation
ISSN
0378-7346
e-ISSN
1423-002X
Volume of the periodical
84
Issue of the periodical within the volume
4
Country of publishing house
CH - SWITZERLAND
Number of pages
9
Pages from-to
360-368
UT code for WoS article
000476516800006
EID of the result in the Scopus database
2-s2.0-85060209944