Vaginal Er:YAG laser application in the menopausal ewe model: a randomised estrogen and sham-controlled trial

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F21%3A43920617" target="_blank" >RIV/00216208:11120/21:43920617 - isvavai.cz</a>

Alternative codes found

RIV/00023698:_____/21:N0000023

Result on the web

<a href="https://doi.org/10.1111/1471-0528.16558" target="_blank" >https://doi.org/10.1111/1471-0528.16558</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/1471-0528.16558" target="_blank" >10.1111/1471-0528.16558</a>

Result language

angličtina

Original language name

Vaginal Er:YAG laser application in the menopausal ewe model: a randomised estrogen and sham-controlled trial

Original language description

OBJECTIVE: To describe effects of non-ablative Er:YAG LASER on vaginal atrophy induced by iatrogenic menopause in the ewe. DESIGN: Animal experimental, randomised, sham and oestrogen-treatment controlled study with blinding for primary outcome. SETTING: KU Leuven, Belgium. SAMPLE: Twenty-four ewes METHODS: Menopause was surgically induced, after which the ewes were randomised to three groups receiving either (1) vaginal Er:YAG LASER application three times, with a one-month interval; (2) three sham manipulations with a month interval; or (3) oestrogen replacement and sham manipulations. At given intervals, ewes were clinically examined and vaginal wall biopsies taken. Vaginal compliance was determined by passive biomechanical testing from explants taken at obduction. MAIN OUTCOME MEASURES: Vaginal epithelial thickness (primary), composition of the lamina propria (collagen, elastin, glycogen and vessels content), vaginal compliance, clinical signs. RESULTS: Animals exposed to Er:YAG LASER application and sham manipulation, but not to oestrogens, displayed a significant and comparable increase in vaginal epithelial thickness between baseline and seven days after the third application (69% and 67% respectively, both p&lt;.0008). In LASER treated ewes, temporary vaginal discharge and limited thermal injury were observed. Oestrogen substituted ewes displayed a more prominent increase in epithelial thickness (202%; p&lt;.0001) and higher vaginal compliance (p &lt;.05). None of the interventions induced changes in the lamina propria. CONCLUSIONS: Vaginal Er:YAG LASER has comparable effect to sham manipulation in menopausal ewes.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30214 - Obstetrics and gynaecology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BJOG: An International Journal of Obstetrics &amp; Gynaecology

ISSN

1470-0328

e-ISSN

—

Volume of the periodical

128

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

1087-1096

UT code for WoS article

000587775900001

EID of the result in the Scopus database

2-s2.0-85096809122