Vaginal changes after ovariectomy in ewes: A large animal model for genitourinary syndrome of menopause
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023698%3A_____%2F23%3AN0000019" target="_blank" >RIV/00023698:_____/23:N0000019 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/23:43925428
Result on the web
<a href="https://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.14816" target="_blank" >https://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.14816</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ijgo.14816" target="_blank" >10.1002/ijgo.14816</a>
Alternative languages
Result language
angličtina
Original language name
Vaginal changes after ovariectomy in ewes: A large animal model for genitourinary syndrome of menopause
Original language description
ObjectiveTo evaluate the effect of iatrogenic menopause on the physiology of the vagina of the ewe and to evaluate if vaginal changes in ewes can be translated to women with genitourinary syndrome of menopause (GSM). MethodsPreclinical research with Dohne Merino ewes. Iatrogenic menopause was induced by bilateral ovariectomy (OVX). Animals were randomized for surgery, blinded for allocation and outcome assessment. Differences between groups were determined by linear regression analyses at 5 months after OVX. Outcome measures were vaginal epithelial thickness, pH, vaginal maturation value, vaginal maturation index, epithelial glycogen accumulation, content of elastin fibers, collagen, and vascularity. ResultsOVX ewes (n = 20) showed epithelial thinning of the vaginal wall from 146 mu m to 47 mu m (mean, P < 0.001). Furthermore, epithelial glycogen accumulation and vascularity of the vaginal wall significantly decreased (43% and 23%, respectively) as compared with the control group (no intervention; n = 5). No significant differences were found for other outcome measures. ConclusionThis study established the ewe as a suitable large animal model for GSM. Furthermore, the similar relevant outcomes in humans and ewes hold great value for future translational research for the evaluation and optimization of different treatment modalities for GSM.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30213 - Transplantation
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
ISSN
0020-7292
e-ISSN
1879-3479
Volume of the periodical
162
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
1042-1049
UT code for WoS article
000982376800001
EID of the result in the Scopus database
2-s2.0-85158123196