No differences were observed in the prevention of necrotizing enterocolitis and late-onset sepsis among preterm infants who received either single-species or multi-species probiotics
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023698%3A_____%2F24%3AN0000012" target="_blank" >RIV/00023698:_____/24:N0000012 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/24:43927054
Result on the web
<a href="https://pubmed.ncbi.nlm.nih.gov/38795665/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/38795665/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.earlhumdev.2024.106054" target="_blank" >10.1016/j.earlhumdev.2024.106054</a>
Alternative languages
Result language
angličtina
Original language name
No differences were observed in the prevention of necrotizing enterocolitis and late-onset sepsis among preterm infants who received either single-species or multi-species probiotics
Original language description
Background: Probiotic prophylaxis has been suggested to reduce the incidence of necrotizing enterocolitis (NEC) and late-onset sepsis (LOS) in very preterm newborns. However, choosing the optimal probiotic is difficult due to variations in strain-specific effects and interactions facilitated by the use of combination species. Aims: To compare clinical outcomes of very preterm infants receiving multi or single-species probiotics. Study design: Retrospective, single-center, cohort study. Subjects: Very preterm infants (<32 weeks' gestation) born between 2019 and 2022 at a tertiary perinatal center received either a multi-species (Lactobacillus rhamnosus 45 %, Lactobacillus casei 15 %, Lactobacillus acidophilus 15 %, Bifidobacterium infantis 15 %, Bifidobacterium bifidum 10 %; n = 228) or a single-species (Bifidobacterium breve BR03 and B632; n = 227) probiotic formulation. Main outcome measures: NEC, LOS, and mortality. Results: The overall incidence of NEC and LOS was 3.1 % and 13.8 %, respectively. There were no differences between the multi-species and single-species probiotic groups in the rate of NEC (3.5 % vs 2.6 %; p = 0.787), LOS (15.4 % vs 12.3 %; p = 0.416), mortality (0.9 % vs 1.8 %; p = 0.449), or composite outcome (NEC, LOS and/ or death; 16.7 % vs 12.8 %; p = 0.290). Conclusion: The clinical outcomes of very preterm newborns receiving multi vs. single-species probiotic formulations were similar in our study. In view of the sample size and low baseline rate of NEC in our unit, further trials are warranted to investigate the effects of specific probiotics for prevention of serious neonatal morbidities.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
EARLY HUMAN DEVELOPMENT
ISSN
0378-3782
e-ISSN
1872-6232
Volume of the periodical
194
Issue of the periodical within the volume
106054
Country of publishing house
IE - IRELAND
Number of pages
5
Pages from-to
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UT code for WoS article
001247365600001
EID of the result in the Scopus database
2-s2.0-85193783679