A synthetic PPAR-? agonist triterpenoid ameliorates experimental fibrosis: PPAR-?-independent suppression of fibrotic responses

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F14%3A%230004001" target="_blank" >RIV/00023728:_____/14:#0004001 - isvavai.cz</a>

Result on the web

<a href="http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=12&SID=T2n3nNQfvLBr1e8jZZA&page=1&doc=7" target="_blank" >http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=12&SID=T2n3nNQfvLBr1e8jZZA&page=1&doc=7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/annrheumdis-2012-202716" target="_blank" >10.1136/annrheumdis-2012-202716</a>

Result language

angličtina

Original language name

A synthetic PPAR-? agonist triterpenoid ameliorates experimental fibrosis: PPAR-?-independent suppression of fibrotic responses

Original language description

The PPAR-? agonist triterpenoid CDDO attenuates fibrogenesis by antagonistically targeting canonical TGF-?/Smad and Akt signalling in a PPAR-?- independent manner. These findings identify this synthetic triterpenoid as a potential new therapy for the control of fibrosis.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ANNALS OF THE RHEUMATIC DISEASES

ISSN

0003-4967

e-ISSN

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Volume of the periodical

73

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

446-454

UT code for WoS article

000329488000003

EID of the result in the Scopus database

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