Changes of patient-reported outcomes and protein fingerprint biomarkers after exercise therapy for axial spondyloarthritis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F19%3AN0000033" target="_blank" >RIV/00023728:_____/19:N0000033 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10373377 RIV/00216208:11510/19:10373377
Result on the web
<a href="https://link.springer.com/article/10.1007/s10067-017-3802-7" target="_blank" >https://link.springer.com/article/10.1007/s10067-017-3802-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10067-017-3802-7" target="_blank" >10.1007/s10067-017-3802-7</a>
Alternative languages
Result language
angličtina
Original language name
Changes of patient-reported outcomes and protein fingerprint biomarkers after exercise therapy for axial spondyloarthritis
Original language description
The objective of this study was to investigate the patient-reported outcomes (PROs) and matrix metalloproteinase (MMP) derived extracellular matrix (ECM) biomarkers in non-radiographic (nr)-axial spondyloarthritis (axSpA) and radiographic (r)-axSpA after exercise intervention. Forty-six axSpA patients with stable disease and treatment underwent 24weeks long exercise intervention. The clinical and laboratory assessments were performed at baseline and at follow-up. The PROs included evaluation of patient's global disease activity (PGDA), disease activity (DA7), pain (PAIN7) and fatigue during last week and quality of life questionnaires. ELISAs for MMP-degraded collagen type II, C-reactive protein (CRPM) and citrullinated vimentin were used. The data of 23 r-axSpA and 19 nr-axSpA were analysed. The PDGA was similar for nr-axSpA (35.2 +/- 18.9) and r-axSpA (33.4 +/- 22.3) at baseline, improved significantly after intervention (p<0.01) and the change of PDGA was almost identical for nr-axSpA (-10.0 +/- 15.4) and r-axSpA (-9.8 +/- 11.9). Evaluations of DA7 and PAIN7 were significantly improved only in nr-axSpA (3.5 +/- 2.3 and 34.7 +/- 25.6 at baseline vs. 2.1 +/- 1.9 and 21.0 +/- 20.5, respectively, p<0.01). The decline of DA7 and PAIN7 was more profound, but not significantly in nr-axSpA than in r-axSpA (-1.4 +/- 1.6 and -13.7 +/- 17.4 vs. -0.5 +/- 3.1 and -3.7 +/- 3.3, respectively). The quality of life was not changed. At baseline, increased levels of CRPM were found in r-axSpA (14.85 +/- 4.10) compared to nr-axSpA (11.83 +/- 3.20), p<0.05, but all three biomarkers were not influenced by exercise therapy. We found that exercise therapy mainly in the nr-axSpA improves PROs, but not ECM turnover biomarkers. This indicates that exercise therapy is important for patients' health but does not affect ECM turnover.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30226 - Rheumatology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CLINICAL RHEUMATOLOGY
ISSN
0770-3198
e-ISSN
1434-9949
Volume of the periodical
38
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
173-179
UT code for WoS article
000456957400022
EID of the result in the Scopus database
2-s2.0-85028583841