Serum visfatin levels in patients with axial spondyloarthritis and their relationship to disease activity and spinal radiographic damage: a cross-sectional study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F19%3AN0000069" target="_blank" >RIV/00023728:_____/19:N0000069 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10399250

Result on the web

<a href="https://doi.org/10.1007/s00296-019-04301-z" target="_blank" >https://doi.org/10.1007/s00296-019-04301-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00296-019-04301-z" target="_blank" >10.1007/s00296-019-04301-z</a>

Result language

angličtina

Original language name

Serum visfatin levels in patients with axial spondyloarthritis and their relationship to disease activity and spinal radiographic damage: a cross-sectional study

Original language description

The purpose of this cross-sectional study was to assess the visfatin levels in patients with axial spondyloarthritis (axSpA) and to investigate the association between visfatin, disease activity and radiographic spinal damage. Serum visfatin levels were determined by enzyme-linked immunosorbent assay in 64 patients with axSpA (46 with radiographic axSpA (r-axSpA) and 18 with non-radiographic axSpA (nr-axSpA)) and 61 age-/sex-matched healthy individuals. Patients with r-axSpA were further divided into two subsets based on radiographic spinal damage using modified Stoke Ankylosing Spondylitis Spine Score (mSASSS=0 and mSASSS1). The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) was used to assess disease activity. C-reactive protein (CRP) levels and human leukocyte antigen (HLA)-B27 were determined. Visfatin levels were significantly higher in patients with axSpA and in the subgroup of patients with r-axSpA than in healthy individuals (p=0.010 and p=0.005, respectively), with no difference between patients with r-axSpA and with nr-axSpA. In general, disease activity was high (mean BASDAI 5.01) and was moderately correlated with visfatin levels (r=0.585; p=0.011) in patients with nr-axSpA. Visfatin levels correlated with mSASSS (r=0.281; p=0.026) and were significantly higher in axSpA patients with mSASSS1 than in those with mSASSS=0 (p=0.025). Our study showed that circulating visfatin levels are elevated in axSpA patients, may be associated with disease activity in early phase of the disease and with the degree of radiographic spinal involvement

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30226 - Rheumatology

Project

<a href="/en/project/NV17-33127A" target="_blank" >NV17-33127A: Evaluation of prognostic factors of early axial spondyloarthritis on the basis of modern biomarkers</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

RHEUMATOLOGY INTERNATIONAL

ISSN

0172-8172

e-ISSN

1437-160X

Volume of the periodical

39

Issue of the periodical within the volume

6

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

1037-1043

UT code for WoS article

000467497400009

EID of the result in the Scopus database

2-s2.0-85065118891