S100A4 is elevated in axial spondyloarthritis: a potential link to disease severity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10419915" target="_blank" >RIV/00216208:11110/20:10419915 - isvavai.cz</a>

Alternative codes found

RIV/00023728:_____/20:N0000062

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lL_espX4sy" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lL_espX4sy</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s41927-019-0110-7" target="_blank" >10.1186/s41927-019-0110-7</a>

Result language

angličtina

Original language name

S100A4 is elevated in axial spondyloarthritis: a potential link to disease severity

Original language description

S100A4 is a member of calcium binding S100 protein family well known for its role in cancer progression and metastasis. Nevertheless, S100A4 also serves as a negative regulator of bone formation. Dickkopf-1 (DKK-1), marker of bone remodelling, is also implicated in the process of syndesmophyte formation in ankylosing spondylitis. The aim of our study was to evaluate plasma levels of S100A4 in patients with axial spondyloarthritis and to determine the potential association of S100A4 with disease severity, clinical manifestations and with bone changes in a cross-sectional study.Fifty-eight patients with axial spondyloarthritis and 40 healthy controls were studied. Biological samples were analysed for S100A4 and Dickkopf-1. Disease activity was assessed according to the Bath Ankylosing Spondylitis Disease Activity Index. C-reactive protein (CRP) was used as a marker of inflammation. Radiographic damage was assessed using the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS).The plasma levels of S100A4 were significantly higher in patients with axial spondyloarthritis compared to heathy controls (p &lt; 0.0001). The levels of S100A4 were higher in early stages of the disease and lower in patients with the presence of syndesmophytes (p = 0.009). Furthermore, we found weak but significant inverse correlation of plasma S100A4 with the mSASSS (r = - 0.363, p = 0.030). Levels of S100A4 were negatively associated with disease duration (r = - 0.404, p = 0.002) and positively with Dickkopf-1 binding capacity (r = 0.312, p = 0.023).

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

—

OECD FORD branch

30226 - Rheumatology

Project

<a href="/en/project/NV17-33127A" target="_blank" >NV17-33127A: Evaluation of prognostic factors of early axial spondyloarthritis on the basis of modern biomarkers</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Rheumatology [online]

ISSN

2520-1026

e-ISSN

—

Volume of the periodical

4

Issue of the periodical within the volume

January

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

13

UT code for WoS article

—

EID of the result in the Scopus database

2-s2.0-85081083008