Role of Heat Shock Protein 90 in Autoimmune Inflammatory Rheumatic Diseases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F19%3AN0000064" target="_blank" >RIV/00023728:_____/19:N0000064 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/chapter/10.1007%2F978-3-030-02254-9_5" target="_blank" >https://link.springer.com/chapter/10.1007%2F978-3-030-02254-9_5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-030-02254-9_5" target="_blank" >10.1007/978-3-030-02254-9_5</a>
Alternative languages
Result language
angličtina
Original language name
Role of Heat Shock Protein 90 in Autoimmune Inflammatory Rheumatic Diseases
Original language description
Hsp90 is the most studied member of the heat shock proteins family (HSP), which are characterized by induction by increased temperature and various other types of stress. It is a highly conserved molecular chaperone that plays a significant role in many cellular processes. Hsp90 is required for the proper conformation and activation of a number of client cellular proteins, including protein kinases, transcription factors and steroid receptors that play an important role in signal transduction. It also regulates activation of innate immunity, antigen presentation, and the induction of proinflammatory cytokines and chemokines by macrophages and dendritic cells. These properties predispose Hsp90 to a potential role in the pathogenesis of autoimmune inflammatory rheumatic diseases. This article provides an overview of the available knowledge about the potential role of Hsp90 in currently studied rheumatic diseases as a promising candidate for targeted therapy or biomarker of disease activity and severity or a predictor of therapeutic response.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30230 - Other clinical medicine subjects
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Chaperokine Activitiy of Heat Shock Proteins
ISBN
978-3-030-02253-2
Number of pages of the result
17
Pages from-to
105-121
Number of pages of the book
320
Publisher name
Springer
Place of publication
Cham
UT code for WoS chapter
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