Treatment with DNases rescues hidden neutrophil elastase from aggregated NETs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F19%3AN0000081" target="_blank" >RIV/00023728:_____/19:N0000081 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10404255
Result on the web
<a href="https://doi.org/10.1002/JLB.3AB0918-370R" target="_blank" >https://doi.org/10.1002/JLB.3AB0918-370R</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/JLB.3AB0918-370R" target="_blank" >10.1002/JLB.3AB0918-370R</a>
Alternative languages
Result language
angličtina
Original language name
Treatment with DNases rescues hidden neutrophil elastase from aggregated NETs
Original language description
The release of neutrophil extracellular traps (NETs) is one of the weapons neutrophils have in their armory. NETs consist of extracellular chromatin fibers decorated with a plethora of cytoplasmic and granular proteins, such as the antimicrobial serine protease neutrophil elastase (NE). Because the first description of NETs as beneficial to the host, reports on their double-faced role in health and disease have considerably increased recently. On one hand, NETs reportedly trap and kill bacteria and also participate in the resolution of the acute inflammation associated with infection and with tissue damage. On the other hand, numerous negative aspects of NETs contribute to the etiopathogenesis of autoimmune disorders. Employing soluble and solid fluorescent substrates, we demonstrate the interaction of NE with aggregated NETs (aggNETs), the limitation of its enzymatic activity and the containment of the enzyme from surrounding tissues. These events prevent the spread of inflammation and tissue damage. The detection of DNase 1-dependent elevation of NE activity attests the continuous presence of patrolling neutrophils forming NETs and aggNETs even under conditions physiologic conditions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30226 - Rheumatology
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF LEUKOCYTE BIOLOGY
ISSN
0741-5400
e-ISSN
1938-3673
Volume of the periodical
106
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
1359-1366
UT code for WoS article
000484750100001
EID of the result in the Scopus database
2-s2.0-85071758476